IgY: A promising antibody for use in immunodiagnostic and in immunotherapy

被引：147

作者：

da Silva, Wilmar Dias ^{[1
]}

Tambourgi, Denise V. ^{[1
]}

机构：

[1] Butantan Inst, Immunochem Lab, BR-05503900 Sao Paulo, Brazil

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2010年 / 135卷 / 3-4期

关键词：

Immunoglobulin; Diversity; Chicken; IgY; Egg; Purification; Immunodiagnostic; Immunotherapy; EGG-YOLK ANTIBODIES; CHICKEN EGG; ESCHERICHIA-COLI; IMMUNOGLOBULINS; DIVERSIFICATION; PURIFICATION; EXPRESSION; SELECTION; LOCUS; CELLS;

D O I：

10.1016/j.vetimm.2009.12.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoglobulin IgY is the major antibody produced by chickens (Gallus domesticus). After their V-C gene is rearranged in B cells, IgY is continually synthesized, excreted into the blood and transferred to the egg yolk, where it is accumulated. IgY is produced by hens to provide their offspring with an effective humoral immunity against the commonest avian pathogens until full maturation of their own immune system. In this review we aim to give an overview about the generation, structure, properties of IgY, as well as the advantages of chicken antibodies use over mammalian antibodies in immunodiagnostics and immunotherapy. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：173 / 180

页数：8

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