Pregnancy-associated plasma protein-a, a marker for outcome in patients suspected for acute coronary syndrome

被引：21
作者：
Iversen, Kasper K. [1 ]
Dalsgaard, Morten [1 ]
Teisner, Ane S. [2 ]
Schoos, Mikkel [1 ]
Teisner, Borge [3 ,4 ]
Nielsen, Henrik [5 ]
Grande, Peer [6 ]
Clemmensen, Peter [6 ]
机构：
[1] Hillerod Hosp, Dept Cardiol, Hillerod, Denmark
[2] Bispebjerg Hosp, Dept Internal Med, Copenhagen Univ Hosp, DK-2400 Copenhagen, Denmark
[3] London Bridge Fertil, Gynaecol & Genet Ctr, London, England
[4] Univ So Denmark, Dept Immunol & Microbiol, Odense, Denmark
[5] Bispebjerg Hosp, Dept Cardiol, Copenhagen Univ Hosp, DK-2400 Copenhagen, Denmark
[6] Rigshosp, Ctr Heart, Copenhagen Univ Hosp, DK-2100 Copenhagen, Denmark
来源：
CLINICAL BIOCHEMISTRY | 2010年 / 43卷 / 10-11期
关键词：
Pregnancy-associated plasma protein A; Acute coronary syndrome; Prognosis; ELEVATION MYOCARDIAL-INFARCTION; PAPP-A; PROGNOSTIC VALUE; ARTERY-DISEASE; ANGINA; ANGIOGRAPHY; STRATEGIES; INHIBITOR; PROFORM; PLAQUE;
D O I：
10.1016/j.clinbiochem.2010.03.018
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objectives: To examine if pregnancy-associated plasma protein-A (PAPP-A) in patients with chest pain, could identify patients at risk for death or myocardial infarction. Design and methods: Patients admitted with chest pain and both normal ECG and normal biomarkers were evaluated by serial measurement of PAPP-A. Main outcome measures were mortality and non-fatal myocardial infarction. Results: Median age of patients included (415) was 67 years and 43% were women. The risk of death or nonfatal myocardial infarction after 3 months was 15% in the highest quartile of circulating PAPP-A compared with 3% in the lowest quartile (relative risk 3.7, p<0.01). Corresponding numbers after 1 year were 24% and 10% (relative risk 2.4, p = 0.01). Conclusion: In patients admitted with chest pain and both normal ECG and normal biomarkers PAPP-A seems to be valuable for predicting patients at high risk of death or non-fatal myocardial infarction. (c) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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收藏
页码：851 / 857
页数：7
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