Trichoderpyrone, a Unique Polyketide Hybrid with a Cyclopentenone-Pyrone Skeleton from the Plant Endophytic Fungus Trichoderma gamsii

被引：22

作者：

Chen, Lin ^{[1
,2
,7
]}

Niu, Shu-Bin ^{[3
]}

Li, Li ^{[4
]}

Ding, Gang ^{[1
,2
]}

Yu, Meng ^{[1
,2
]}

Zhang, Gui-shan ^{[5
]}

Wang, Meng-hua ^{[1
,2
]}

Li, Lu-ying ^{[1
,2
]}

Zhang, Tao ^{[1
,2
]}

Jia, Hong-Mei ^{[1
,2
]}

Zhang, Hong-wu ^{[1
,2
]}

Shang, Hai ^{[1
,2
]}

Liu, Xing-zhong ^{[6
]}

Zou, Zhong-mei ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100193, Peoples R China

[2] Peking Union Med Coll, Beijing 100193, Peoples R China

[3] Beijing City Univ, Sch Biol Med, Beijing 450046, Peoples R China

[4] Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[5] Chinese Acad Agr Sci, Inst Agr Resources & Reg Planning, Minist Agr, Key Lab Microbial Resources Collect & Preservat, Beijing 100081, Peoples R China

[6] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100090, Peoples R China

[7] Huanghe Sci & Technol Coll, Inst Nanostruct Funct Mat, Zhengzhou Key Lab Med Resources Res, Zhengzhou 450006, Henan, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 06期

基金：

中国国家自然科学基金;

关键词：

DERIVATIVES;

D O I：

10.1021/acs.jnatprod.7b00190

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Trichoderpyrone (1), a unique polyketide with a cyclopentenone-pyrone hybrid skeleton, was isolated from the plant endophytic fungus Trichoderma gamsii. The structure of 1 was determined by detailed analysis of NMR data together with comparison of chemical shift values of similar fragments. The relative and absolute configurations were established by NOESY correlations and CD experiment. Trichoderpyrone (1) displayed weak cytotoxic activities against A549, HepG2, and HeLa cancer cell lines. 1 might originate from a hybrid biosynthetic pathway through two nonreduced (NR) polyketide megasynthetases.

引用

页码：1944 / 1947

页数：4

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