Absolute stereochemistry of vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic

被引：23

作者：

Arai, H

Matsushima, Y

Eguchi, T

Shindo, K

Kakinuma, K ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 152, Japan

[2] Kirin Brewery Co Ltd, Pharmaceut Res Lab, Takasaki, Gumma 37012, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 20期

基金：

日本学术振兴会;

关键词：

macrolactam; antitumor antibiotic; absolute stereochemistry;

D O I：

10.1016/S0040-4039(98)00454-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The absolute stereochemistry of the aglycon part of an antitumor antibiotic vicenistatin (1) was determined by a synthetic approach. Two relevant components degradatively derived from natural 1 were compared with the corresponding synthetic standards prepared from known compounds by stereochemically defined chemistry. The absolute configuration of 1 turned out to be 6S,7S,18S, (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3181 / 3184

页数：4

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