Investigations of TB vaccine-induced mucosal protection in mice

被引：9
作者：
Blazevic, Azra [1 ]
Eickhoff, Christopher S. [1 ]
Stanley, Jaime [1 ]
Buller, Mark R. [2 ]
Schriewer, Jill [2 ]
Kettelson, Eric M. [2 ]
Hoft, Daniel F. [1 ,2 ]
机构：
[1] St Louis Univ, Dept Internal Med, Doisy Res Ctr, St Louis, MO 63104 USA
[2] St Louis Univ, Dept Mol Microbiol & Immunol, Doisy Res Ctr, St Louis, MO 63104 USA
来源：
MICROBES AND INFECTION | 2014年 / 16卷 / 01期
关键词：
Mycobacterium tuberculosis (Mtb); BCG; Vaccination; Mucosal specific immunity; CALMETTE-GUERIN VACCINATION; MYCOBACTERIUM-BOVIS; TUBERCULOSIS; PROTEIN; IMMUNIZATION; EFFICACY; GAMMA; DNA; IMMUNOGENICITY; METAANALYSIS;
D O I：
10.1016/j.micinf.2013.09.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A better understanding of mucosal immunity is required to develop more protective vaccines against Mycobacterium tuberculosis. We developed a murine aerosol challenge model to investigate responses capable of protecting against mucosal infection. Mice received vaccinations intranasally with CpG-adjuvanted antigen 85B (Ag85B/CpG) and/or Bacillus Calmette Guerin (BCG). Protection against aerosol challenge with a recombinant GFP-expressing BCG was assessed. Mucosal prime/boost vaccinations with Ag85B/CpG and BCG were protective, but did not prevent lung infection indicating more efficacious mucosal vaccines are needed. Our novel finding that protection correlated with increased airway dendritic cells early post-challenge could help guide the development of enhanced mucosal vaccines. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：73 / 79
页数：7
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