Expression of βE and γ-globin genes in infants heterozygous for hemoglobin E and double heterozygous for hemoglobin E and α-thalassemia

被引：3
|
作者：
Winichagoon, Pranee
Svasti, Saovaros
Winichagoon, Pattanee
Chitchumroonchokchai, Chureeporn
Fucharoen, Suthat
机构：
[1] Mahidol Univ, Inst Sci & Technol Res & Dev, Thalassemia Res Ctr, Nakhon Pathom 73170, Thailand
[2] Mahidol Univ, Inst Nutr, Nakhon Pathom 73170, Thailand
来源：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2007年 / 92卷 / 05期
关键词：
thalassemia; hemoglobin E; hemoglobin F; neonatal screening; globin gene expression;
D O I：
10.3324/haematol.10930
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study described the expression of beta(E)-globin in newborns heterozygous for HbE. Despite the lower level of HbE, the pattern of beta(E)-globin gene expression was similar to beta(A)-globinn because the increase in HbE and HbA reached the peak level at the same time. A delayed decline of HbF was observed.
引用
收藏
页码：702 / 703
页数：2
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