FOXC1 Is a Potential Prognostic Biomarker with Functional Significance in Basal-like Breast Cancer

被引：213

作者：

Ray, Partha S. ^{[2
]}

Wang, Jinhua ^{[1
]}

Qu, Ying ^{[1
,5
]}

Sim, Myung-Shin ^{[3
]}

Shamonki, Jaime ^{[4
]}

Bagaria, Sanjay P. ^{[2
]}

Ye, Xing ^{[3
]}

Liu, Bingya ^{[5
]}

Elashoff, David ^{[6
]}

Hoon, Dave S. ^{[1
]}

Walter, Michael A. ^{[7
]}

Martens, John W. ^{[8
]}

Richardson, Andrea L. ^{[9
]}

Giuliano, Armando E. ^{[2
]}

Cui, Xiaojiang ^{[1
]}

机构：

[1] John Wayne Canc Inst, Dept Mol Oncol, Santa Monica, CA 90404 USA

[2] John Wayne Canc Inst, Dept Surg Oncol, Santa Monica, CA 90404 USA

[3] John Wayne Canc Inst, Dept Biostat, Santa Monica, CA 90404 USA

[4] St Johns Hlth Ctr, Dept Pathol, Santa Monica, CA USA

[5] Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Surg, Shanghai 200030, Peoples R China

[6] Univ Calif Los Angeles, Sch Med, Div Gen Internal Med, Los Angeles, CA USA

[7] Univ Alberta, Dept Med Genet, Edmonton, AB, Canada

[8] Erasmus MC, Dept Med Oncol, Rotterdam, Netherlands

[9] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

CANCER RESEARCH | 2010年 / 70卷 / 10期

关键词：

EXPRESSION SIGNATURE; MOLECULAR PORTRAITS; TUMORS; IDENTIFICATION; CARCINOMA; SURVIVAL; SUBTYPES; PREDICTOR; PATTERNS; FEATURES;

D O I：

10.1158/0008-5472.CAN-09-4120

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gene expression signatures for a basal-like breast cancer (BLBC) subtype have been associated with poor clinical outcomes, but a molecular basis for this disease remains unclear. Here, we report overexpression of the transcription factor FOXC1 as a consistent feature of BLBC compared with other molecular subtypes of breast cancer. Elevated FOXC1 expression predicted poor overall survival in BLBC (P = 0.0001), independently of other clinicopathologic prognostic factors including lymph node status, along with a higher incidence of brain metastasis (P = 0.02) and a shorter brain metastasis-free survival in lymph node-negative patients (P < 0.0001). Ectopic overexpression of FOXC1 in breast cancer cells increased cell proliferation, migration, and invasion, whereas shRNA-mediated FOXC1 knockdown yielded opposite effects. Our findings identify FOXC1 as a theranostic biomarker that is specific for BLBC, offering not only a potential prognostic candidate but also a potential molecular therapeutic target in this breast cancer subtype. Cancer Res; 70(10); 3870-6. (C) 2010 AACR.

引用

页码：3870 / 3876

页数：7

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