Poor prognosis of Candida tropicalis among non-albicans candidemia: a retrospective multicenter cohort study, Korea

被引：32

作者：

Ko, Jae-Hoon ^{[1
]}

Jung, Dong Sik ^{[2
]}

Lee, Ji Yeon ^{[3
]}

Kim, Hyun Ah ^{[3
]}

Ryu, Seong Yeol ^{[3
]}

Jung, Sook-In ^{[4
]}

Joo, Eun-Jeong ^{[5
]}

Cheon, Shinhye ^{[6
]}

Kim, Yeon-Sook ^{[6
]}

Kim, Shin-Woo ^{[7
]}

Cho, Sun Young ^{[1
]}

Kang, Cheol-In ^{[1
]}

Chung, Doo Ryeon ^{[1
]}

Lee, Nam Yong ^{[7
]}

Peck, Kyong Ran ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis,Dept Med, Seoul, South Korea

[2] Dong A Univ, Div Infect Dis, Coll Med, Busan, South Korea

[3] Keimyung Univ, Div Infect Dis, Dongsan Med Ctr, Daegu, South Korea

[4] Chonnam Natl Univ Hosp, Div Infect Dis, Gwangju, South Korea

[5] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Infect Dis,Sch Med, Seoul, South Korea

[6] Chungnam Natl Univ, Div Infect Dis, Sch Med, Daejeon, South Korea

[7] Sungkyunkwan Univ, Samsung Med Ctr, Dept Lab Med, Sch Med, Seoul, South Korea

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2019年 / 95卷 / 02期

关键词：

Non-albicans candidemia; Clinical outcome; Poor prognosis; Candida tropicalis; INFECTIOUS-DISEASES SOCIETY; CLINICAL-PRACTICE GUIDELINE; BLOOD-STREAM INFECTION; ANTIFUNGAL SUSCEPTIBILITY; AMPHOTERICIN-B; FLUCONAZOLE; UPDATE; VORICONAZOLE; MANAGEMENT; FUNGEMIA;

D O I：

10.1016/j.diagmicrobio.2019.05.017

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

To evaluate clinical features and prognostic factors of non-albicans candidemia, we conducted a retrospective multicenter cohort study at 7 university hospitals in Korea from January 2010 to February 2016. A total of 721 patients with non-albicans candidemia were included in the analysis. C tropicalis was most commonly identified (36.5%), followed by C. glabrata (27.2%), C. parapsilosis (25.7%), and C. krusei (2.4%). Clinical presentation of C. tropicalis candidemia was most severe with highest median C-reactive protein level (10.1 mg/dL) and Acute Physiology and Chronic Health Evaluation II score (14, both P << 0.05). C. tropicalis showed the highest 14- and 30-day mortality (28.9% and 44.1%). In multivariate analysis, C. tropicalis infection was significantly related with 14- (P = 0.005) and 30-day mortality (P = 0.033). In conclusion, C. tropicalis infection presented most severely and showed worst clinical outcome among non-albicans candidemia. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：195 / 200

页数：6

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