Microwave-Assisted Synthesis of Nitro-Substituted Tetrahydropyridoazepines

被引：5

作者：

Schultz, Thomas ^{[1
]}

Turner, Sean C. ^{[1
]}

Braje, Wilfried M. ^{[1
]}

机构：

[1] Abbott GmbH & Co KG, D-67061 Ludwigshafen, Germany

来源：

SYNTHESIS-STUTTGART | 2010年 / 08期

关键词：

ketones; condensation; regioselectivity; heterocycles; pyridines; DIELS-ALDER REACTIONS; ORGANIC-SYNTHESIS; HETEROCYCLES; DERIVATIVES;

D O I：

10.1055/s-0029-1218678

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The microwave-assisted condensation of azepan-4-ones with 3,5-dinitro-1-methylpyridin-2-one in the presence of ammonia was found to be a highly efficient method for the synthesis of nitro-substituted tetrahydropyridoazepines. Variation of the substituent at the amino group enables the regioselective synthesis of tetrahydropyrido[3,2-c]azepines and tetrahydropyrido[2,3-d]azepines.

引用

页码：1339 / 1343

页数：5

共 21 条

[1]

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[2]

ARALDI GL, 2007, Patent No. 2007140213

[3]

BAMFORD MJ, 2004, Patent No. 2004056369

[4]

BROMIDGE SM, 2003, Patent No. 2003068752