Refined deletion mapping in sporadic breast cancer at chromosomal region 8p12-p21 and association with clinicopathological parameters

被引：23
|
作者：
Seitz, S
Werner, S
Fischer, J
Nothnagel, A
Schlag, PM
Scherneck, S
机构：
[1] Max Delbruck Ctr Mol Med, Dept Tumor Genet, D-13122 Berlin, Germany
[2] Robert Roessle Hosp, Dept Med Informat, D-13122 Berlin, Germany
[3] Robert Roessle Hosp, Dept Surg & Surg Oncol, D-13122 Berlin, Germany
来源：
EUROPEAN JOURNAL OF CANCER | 2000年 / 36卷 / 12期
关键词：
breast cancer; chromosomal region 8p12-p21; loss of heterozygosity; clinicopathological parameters;
D O I：
10.1016/S0959-8049(00)00135-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have further refined the loss of heterozygosity (LOH) pattern on the human chromosomal region 8p12-p21 using 15 well characterised microsatellite markers in a panel of 50 breast carcinomas. The allelic loss pattern of these rumours suggests the presence of five commonly deleted regions on 8p12-p21. The most commonly deleted region was located between markers D8S1734 and D81989, spanning a distance of approximately 3 cM and reaching 56% LOH at locus NEFL. LOH at 8p12-p21 was significantly correlated with large tumour size (T > 5 cm). Patients with the age at diagnosis of breast cancer between 45 and 55 years showed significantly more LOH than patients older than 55 years or younger than 45 years. No correlation was observed between 8p12-p21 alterations and histological tumour type, grade and the presence of lymph node metastases. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1507 / 1513
页数：7
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