Synergetic Control for HIV Infection System of CD4+T Cells

The HIV infection system is one of the important dynamical systems of viruses, which have been interested by many researchers. In particular, there are several studies on the use of nonlinear feedback control to determine the treatment. The aim of the treatment is to control the amount of uninfected CD4(+)T cells to the desired level, and to drive the amount of infected CD4(+)T cells and free virus particles approach to zero as time increased. One well known nonlinear control method is the synergetic control which has been employed for many nonlinear engineering systems. Thus the main focus of this study is to investigate the capability of the synergetic control applying on HIV system. The synergetic control was applied on the HIV system to define the treatment. The study was conducted via simulation. The simulation of the controlled HIV system showed that the state variables approach to the desired values. Therefore, the synergetic controller is feasible to determine the treatment for HIV infection.