Association of IL-6-176G > C Polymorphism with Susceptibility to Preeclampsia: A Systematic Review and Meta-Analysis

被引：7

作者：

Veisian, Mehrnaz ^{[1
]}

Javaheri, Atiyeh ^{[2
]}

Amjadi, Nooshin ^{[3
]}

Tabatabaei, Razieh Sadat ^{[2
]}

Zanbagh, Leila ^{[2
,4
]}

Hadadan, Amaneh ^{[2
,3
]}

Abbasi, Hajar ^{[3
]}

Salimi, Erfaneh ^{[3
]}

Dastgheib, Seyed Alireza ^{[5
]}

Neamatzadeh, Hossein ^{[6
,7
]}

机构：

[1] Isfahan Univ Med Sci, Dept Gynecol & Obstet, Esfahan, Iran

[2] Shahid Sadoughi Univ Med Sci, Dept Gynecol & Obstet, Yazd, Iran

[3] Shahid Beheshti Univ Med Sci, Dept Gynecol & Obstet, Tehran, Iran

[4] Univ Tehran Med Sci, Dept Gynecol & Obstet, Tehran, Iran

[5] Shiraz Univ Med Sci, Sch Med, Dept Med Genet, Shiraz, Iran

[6] Shahid Sadoughi Univ Med Sci, Dept Med Genet, Yazd, Iran

[7] Shahid Sadoughi Univ Med Sci, Mother & Newborn Hlth Res Ctr, Yazd, Iran

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2020年 / 39卷 / 06期

关键词：

Preeclampsia; interleukin; 6; polymorphism; association; meta-analysis; NECROSIS-FACTOR-ALPHA; PROMOTER POLYMORPHISM; INTERLEUKIN-10; CANCER; GENES; WOMEN;

D O I：

10.1080/15513815.2019.1675110

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Background: Many studies have described the influence of -176G > C polymorphism of the IL-6 gene on susceptibility to preeclampsia. However, the results have remained inconclusive and controversial. Therefore, we performed a meta-analysis to more precisely determine the association between the IL-6 -176G > C polymorphism and preeclampsia risk. Methods: Electronic databases including PubMed, Embase, Web of Science, and CNKI were searched up to August 15, 2019. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were used to calculate the association. Results: A total of 12 studies with 1,821 preeclampsia cases and 3,339 controls were selected. Overall, no significant association was found between IL-6 -176G > C polymorphism and preeclampsia risk. In the stratified analyses by ethnicity, there was a significant association in Asians, but not in Caucasians and mixed populations. Conclusions: The results of meta-analysis indicated that IL-6 -176G > C polymorphism was not significantly associated with risk of preeclampsia in overall population.

引用

页码：491 / 502

页数：12

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