Paramylon, a Potent Immunomodulator from WZSL Mutant of Euglena gracilis

被引：43

作者：

Barsanti, Laura ^{[1
]}

Gualtieri, Paolo ^{[1
]}

机构：

[1] CNR, Ist Biofis, Via Moruzzi 1, I-56124 Pisa, Italy

来源：

MOLECULES | 2019年 / 24卷 / 17期

关键词：

beta-glucans; immune system; PAMPs; PRRs; glucan source; glucan extraction; Euglena gracilis; BETA-GLUCAN RECOGNITION; FED-BATCH; DECTIN-1; RESISTANCE; ACTIVATION; FIBROSIS; RECEPTOR; GROWTH; FRUITS; ROLES;

D O I：

10.3390/molecules24173114

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

beta-glucans, heterogeneous glucose polymers present in many organisms, have the capability to activate the innate immune system. Efficacy of activation depends on purity of the compound, molecular structure, polymerization degree, and source. One of the purest forms of crystallized beta-(1-3)-glucan present in nature is the paramylon extracted from the WZSL non-chloroplastic mutant of Euglena gracilis, which can be processed to produce linear nanofibers capable of interacting with specific receptors present on cell membranes. The effects of these nanofibers, already investigated on plants, animals, and humans, will be analyzed.

引用

页数：14

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