An efficient InCl3-catalyzed hydration of nitriles to amides: acetaldoxime as an effective water surrogate

被引：67
作者：
Kim, Eun Sun
Lee, Hyun Seung
Kim, Sung Hwan
Kim, Jae Nyoung [1 ]
机构：
[1] Chonnam Natl Univ, Dept Chem, Kwangju 500757, South Korea
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 12期
关键词：
Indium chloride; Hydration; Nitriles; Amides; Acetaldoxime; CATALYZED HYDRATION; HYDROXIDE CATALYST; NEUTRAL CONDITIONS; HYDROGEN-PEROXIDE; AQUEOUS-MEDIUM; ONE-POT; ALDOXIMES; CONVERSION; HYDROLYSIS; ORGANONITRILES;
D O I：
10.1016/j.tetlet.2010.01.063
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient InCl3-catalyzed hydration protocol of nitrites to amides was developed. The reaction was carried Out in toluene at refluxing temperature with the aid of acetaldoxime as an effective water surrogate to produce amides in high yields. (C) 2010 Elsevier Ltd. All rights reserved.
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收藏
页码：1589 / 1591
页数：3
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