Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

被引：109
作者：
Sanders, Karin J. C. [1 ]
Kneppers, Anita E. M. [1 ]
van de Bool, Coby [1 ]
Langen, Ramon C. J. [1 ]
Schols, Annemie M. W. J. [1 ]
机构：
[1] NUTRIM Sch Nutr & Translat Res Metab, Dept Resp Med, Maastricht, Netherlands
来源：
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE | 2016年 / 7卷 / 01期
关键词：
COPD; Muscle; Emphysema; Energy balance; Cachexia; Lung cancer; BROWN ADIPOSE-TISSUE; RESTING ENERGY-EXPENDITURE; LUNG-VOLUME REDUCTION; CHRONIC HEART-FAILURE; HUMAN SKELETAL-MUSCLE; DAILY PHYSICAL-ACTIVITY; DOUBLY LABELED WATER; FAT-FREE MASS; BODY-COMPOSITION; SATELLITE CELLS;
D O I：
10.1002/jcsm.12062
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Cachexia and muscle wasting are well recognized as common and partly reversible features of chronic obstructive pulmonary disease (COPD), adversely affecting disease progression and prognosis. This argues for integration of weight and muscle maintenance in patient care. In this review, recent insights are presented in the diagnosis of muscle wasting in COPD, the pathophysiology of muscle wasting, and putative mechanisms involved in a disturbed energy balance as cachexia driver. We discuss the therapeutic implications of these new insights for optimizing and personalizing management of COPD-induced cachexia.
引用
收藏
页码：5 / 22
页数：18
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