Amantadine for levodopa-induced choreic dyskinesia in compound heterozygotes for GCH1 mutations

被引：12
作者：
Furukawa, Y
Filiano, JJ
Kish, SJ
机构：
[1] Ctr Addict & Mental Hlth, Clarke Div, Movement Disorders Res Lab, Toronto, ON M5T 1R8, Canada
[2] Dartmouth Hitchcock Med Ctr, Dept Pediat Neurol, Lebanon, NH 03766 USA
[3] Ctr Addict & Mental Hlth, Clarke Div, Human Neurochem Pathol Lab, Toronto, ON M5T 1R8, Canada
来源：
MOVEMENT DISORDERS | 2004年 / 19卷 / 10期
关键词：
amantadine; levodopa-induced dyskinesias; GTP cyclohydrolase I deficiency;
D O I：
10.1002/mds.20194
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Amantadine suppressed severe levodopa-induced choreic dyskinesia, which developed at initiation of levodopa therapy, in two siblings manifesting dystonia with motor delay phenotype of GTP cyclohydrolase 1 deficiency caused by compound heterozygous GCH1 mutations. Our finding suggests a beneficial effect of amantadine on this type of dyskinesia frequently observed in relatively severe dopamine-deficient metabolic disorders. (C) 2004 Movement Disorder Society.
引用
收藏
页码：1256 / 1258
页数：3
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