Antivirals and antiviral strategies

被引：290

作者：

De Clercq, E ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

NATURE REVIEWS MICROBIOLOGY | 2004年 / 2卷 / 09期

关键词：

D O I：

10.1038/nrmicro975

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In recent years, the demand for new antiviral strategies has increased markedly. There are many contributing factors to this increased demand, including the ever-increasing prevalence of chronic viral infections such as HIV and hepatitis B and C, and the emergence of new viruses such as the SARS coronavirus. The potential danger of haemorrhagic fever viruses and eradicated viruses such as variola virus being used as bioterrorist weapons has also increased the profile of antiviral drug discovery. Here, the virus infections for which antiviral therapy is needed and the compounds that are available, or are being developed, for the treatment of these infections are described.

引用

页码：704 / 720

页数：17

共 127 条

[1] Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers [J].

Abdulkarim, B ;

Sabri, S ;

Deutsch, E ;

Chagraoui, H ;

Maggiorella, L ;

Thierry, J ;

Eschwege, F ;

Vainchenker, W ;

Chouaïb, S ;

Bourhis, J .

ONCOGENE, 2002, 21 (15) :2334-2346

[2] Increased antiviral activity of 1-O-hexadecyloxypropyl-[ 2-14C] cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism [J].

Aldern, KA ;

Ciesla, SL ;

Winegarden, KL ;

Hostetler, KY .

MOLECULAR PHARMACOLOGY, 2003, 63 (03) :678-681

[3] Coronavirus main proteinase (3CLpro) structure:: Basis for design of anti-SARS drugs [J].

Anand, K ;

Ziebuhr, J ;

Wadhwani, P ;

Mesters, JR ;

Hilgenfeld, R .

SCIENCE, 2003, 300 (5626) :1763-1767

[4]

Andrei G, 2004, ANTIVIR RES, V62, pA61

[5] INHIBITORY EFFECT OF SELECTED ANTIVIRAL COMPOUNDS ON ARENAVIRUS REPLICATION INVITRO [J].

ANDREI, G ;

DECLERCQ, E .

ANTIVIRAL RESEARCH, 1990, 14 (4-5) :287-300

[6] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells [J].

Andrei, G ;

Snoeck, R ;

Schols, D ;

De Clercq, E .

ONCOLOGY RESEARCH, 2001, 12 (9-10) :397-408

[7] Activities of various compounds against murine and primate polyomaviruses [J].

Andrei, G ;

Snoeck, R ;

Vandeputte, M ;

DeClercq, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (03) :587-593

[8] Mechanism of action of a pestivirus antiviral compound [J].

Baginski, SG ;

Pevear, DC ;

Seipel, M ;

Sun, SCC ;

Benetatos, CA ;

Chunduru, SK ;

Rice, CM ;

Collett, MS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (14) :7981-7986

[9] Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections [J].

Baker, R ;

Bray, M ;

Huggins, JW .

ANTIVIRAL RESEARCH, 2003, 57 (1-2) :13-23

[10]

Balzarini J, 2004, ANTIVIR RES, V62, pA59

← 1 2 3 4 5 6 7 8 9 10 →