Stereoselective synthesis of a conformationally restricted beta-hydroxy-gamma-amino acid

被引：7
作者：
Xiao, D
Carroll, PJ
Mayer, SC
Pfizenmayer, AJ
Joullie, MM
机构：
[1] UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104
[2] WYETH AYERST RES,MONMOUTH JCT,NJ 08852
来源：
TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 18期
关键词：
D O I：
10.1016/S0957-4166(97)00402-3
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
beta-Hydroxy-gamma-amino acids are a class of non-proteinogenic amino acids present in many important biologically active natural products. In conjunction with our research on didemnins, we designed and synthesized a sterically constrained beta-hydroxy-gamma-amino acid in which the requisite carboxyl, hydroxyl and amino groups are positioned on a conformationally stable 6-membered ring. (C) 1997 Elsevier Science Ltd.
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页码：3043 / 3046
页数：4
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