Novel Biomarkers for Coronary Restenosis Occurrence After Drug-Eluting Stent Implantation in Patients With Diabetes Having Stable Coronary Artery Disease

被引:14
作者
Gabbasov, Zufar [1 ]
Kozlov, Sergey [1 ]
Melnikov, Ivan [1 ,2 ]
Byazrova, Svetlana [1 ]
Saburova, Olga [1 ]
Prokofieva, Lyudmila [1 ]
Caprnda, Martin [3 ]
Curilla, Eduard [4 ]
Gaspar, Ludovit [3 ]
Rodrigo, Luis [5 ]
Kruzliak, Peter [6 ,7 ,8 ]
Smirnov, Vladimir [1 ]
机构
[1] Russian Cardiol Res & Prod Complex, Moscow, Russia
[2] Russian Acad Sci, Inst Biomed Problems, Moscow, Russia
[3] Comenius Univ, Dept Internal Med 1, Fac Med, Bratislava, Slovakia
[4] East Slovak Inst Cardiovasc Dis, Dept Cardiol, Kosice, Slovakia
[5] Univ Oviedo, Fac Med, Cent Univ Hosp Asturias HUCA, Oviedo, Spain
[6] Bros Mercy Hosp, Dept Internal Med, Polni 3, Brno 63900, Czech Republic
[7] Masaryk Univ, Dept Surg 2, Fac Med, Brno, Czech Republic
[8] St Annes Univ Hosp, Brno, Czech Republic
基金
俄罗斯科学基金会;
关键词
coronary artery disease; diabetes mellitus; drug-eluting stents; restenosis; CD45+platelet count; neutrophil to lymphocyte ratio; C-REACTIVE PROTEIN; LYMPHOCYTE RATIO; MYOCARDIAL-INFARCTION; ELEVATED NEUTROPHIL; MICROPARTICLES; INTERVENTION; DISSOCIATION; INFLAMMATION; LOCALIZES; MORTALITY;
D O I
10.1177/1076029618771752
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The purpose of the study was to assess whether the occurrence of restenosis is associated with CD45+ platelet count and neutrophil to lymphocyte ratio in patients with type 2 diabetes mellitus (DM) after drug-eluting stent (DES) implantation for stable coronary artery disease (CAD). The study comprised 126 patients, including 55 patients with type 2 DM and stable CAD who underwent elective coronary artery stenting with DES and follow-up angiography within 6 to 12 months. Blood samples were collected from each patient on the morning of the coronary angiography procedure. The variables related to in-stent restenosis were selected by logistic regression analysis. The logistic regression analysis showed that 2 inflammatory factors, CD45+ platelet count (odds ratio [OR] = 4.51, 95% confidence interval [CI]: 1.50-13.50, P = .007) and neutrophil to lymphocyte ratio (OR = 3.09, 95% CI: 1.05-9.10, P = .04), were significantly associated with the risk of in-stent restenosis after stenting with DES in patients with stable CAD and type 2 DM. A receiver operator characteristic curve analysis indicated that the area under the curve was 0.83% (0.05%; P < .001), which showed that the logistic model had good predictive accuracy (based on CD45+ platelet count and neutrophil to lymphocyte ratio) for the risk of in-stent restenosis development in DES in patients with CAD and type 2 DM. Two novel biomarkers of restenosis, CD45+ platelet count and neutrophil to lymphocyte ratio, may be effectively used to predict in-stent restenosis after DES implantation in patients with CAD and type 2 DM.
引用
收藏
页码:1308 / 1314
页数:7
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