The impact assessment of anticancer drug imatinib on the feeding behavior of rotifers with an integrated perspective: Exposure, post-exposure and re-exposure

被引:10
作者
Yan, Zhengyu [1 ]
Yan, Kun [1 ]
He, Xingliang [2 ]
Liu, Yanhua [1 ]
Zhang, Jie [1 ]
Torres, Oscar Lopez [1 ]
Guo, Ruixin [1 ]
Chen, Jianqiu [1 ]
机构
[1] China Pharmaceut Univ, Key Lab Drug Qual Control & Pharmacovigilance, Minist Educ, Nanjing 210009, Jiangsu, Peoples R China
[2] Nanjing Police Dog Res Inst, Minist Publ Secur, Nanjing 210012, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
Imatinib; Rotifers; Feeding behavior; Post-exposure; AchE; ROS; AQUATIC ORGANISMS; BRACHIONUS-PLICATILIS; CYTOSTATIC DRUGS; METAL EXPOSURE; SURFACE WATERS; HEAVY-METALS; TOXICITY; OVERCOMPENSATION; ADAPTATION; PHARMACEUTICALS;
D O I
10.1016/j.chemosphere.2017.07.043
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The anticancer drugs are getting increasing attention as an emerging contaminant in the aquatic environments. In the present study, feeding behavior of the rotifer Brachionus calyciflorus under the impact of anticancer drug imatinib was evaluated. Traditional toxicological studies usually focus on dose-effect relationship at a given exposure time, while ignore the possible impact after the exposure. Thus, how the impact varied in the post-exposure and re-exposure was also considered in the present study. The feeding depression of the rotifers was attributed to the increased concentration of imatinib. Although the filtration and ingestion rate of the rotifers recovered to a certain extent after the exposure, the significant feeding inhibition still persisted even if the exposure was ended. In the re-exposure period, the feeding behavior was less depressed than those of the exposure period, which implied that rotifers might develop a tolerance to the same toxics. The activities of acetylcholine esterase (AchE) and the levels of reactive oxygen species (ROS) in rotifers were also detected. Imatinib inhibited the activities of AchE in the exposure and re-exposure while ROS levels increased significantly in the re-exposure period. Our present study provided an integrated assessment the potential environmental risks of imatinib at a new perspective. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:423 / 430
页数:8
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