Photodynamic activity of thiophene-derived lysosome-specific dyes

被引：8
作者：
Baldassarre, Francesca [1 ]
Foglietta, Federica [2 ]
Vergaro, Viviana [1 ]
Barbero, Nadia [3 ,4 ]
Capodilupo, Agostina L. [5 ]
Serpe, Loredana [2 ]
Visentin, Sonja [6 ]
Tepore, Antonio [7 ]
Ciccarella, Giuseppe [1 ,5 ]
机构：
[1] Univ Salento, Biol & Environm Sci Dept, Via Monteroni, I-73100 Lecce, Italy
[2] Univ Torino, Dept Drug Sci & Technol, Via P Giuria 9, I-10125 Turin, Italy
[3] Univ Torino, Dept Chem, Via P Giuria 7, I-10125 Turin, Italy
[4] Univ Torino, Dept Chem, NIS Interdept Ctr, Via P Giuria 7, I-10125 Turin, Italy
[5] CNR NANOTEC, Inst Nanotechnol, Via Monteroni, I-73100 Lecce, Italy
[6] Univ Torino, Dept Mol Biotechnol & Hlth Sci, Dept Innovat Ctr, Via Quarello 15B, I-10135 Turin, Italy
[7] Univ Salento, Dept Cultural Heritage, Via Monteroni, I-73100 Lecce, Italy
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2016年 / 158卷
关键词：
Thiophene dyes; Lysosomes; Photosensitizers; Singlet oxygen; Reactive oxygen species; Human serum albumin; HUMAN-SERUM-ALBUMIN; VIVO PHOTOSENSITIZING EFFICACY; CELL-DEATH; FLUORESCENT-PROBES; SINGLET OXYGEN; THERAPY; APOPTOSIS; ACTIVATION; INDUCTION; PERMEABILIZATION;
D O I：
10.1016/j.jphotobiol.2016.02.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The photodynamic activity occurring through the lysosome photo-damage is effective in terms of triggered synergic effects which can avoid chemo-resistance pathways. The potential photodynamic activity of two fluorescent lysosome-specific probes was studied providing their interaction with human serum albumin, demonstrating their in vitro generation of singlet oxygen and investigating the resulted photo-toxic effect in human cancer cells. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：16 / 22
页数：7
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