The role of functional polymorphisms of the TNF-α gene promoter in the risk of ischemic stroke in Chinese Han and Uyghur populations: Two case-control studies

被引：21

作者：

Tong, Yeqing ^{[1
,3
]}

Geng, Yijie ^{[2
]}

Xu, Jing ^{[1
]}

Wang, Zhihong ^{[3
]}

Zhang, Yanwei ^{[2
]}

Lin, Liangqiang ^{[2
]}

Zhang, Renli ^{[2
]}

Deng, Pingjian ^{[2
]}

Li, Yongbin ^{[1
]}

Hou, Wanli ^{[1
]}

Chai, Yun ^{[1
]}

Mason, Katherine A. ^{[4
]}

Lu, Zuxun ^{[1
,3
]}

Cheng, Jinquan ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth,Dept Social Med & Hlth Management, Key Lab Chron Dis Prevent,Inst Social Med, Wuhan 430030, Peoples R China

[2] Shenzhen Ctr Dis Controls & Prevent, Key Lab Mol Biol Guangdong Prov, Shenzhen 518020, Peoples R China

[3] Huazhong Univ Sci & Technol, Liyuan Hosp, Inst Gerontol, Wuhan 430030, Peoples R China

[4] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

来源：

CLINICA CHIMICA ACTA | 2010年 / 411卷 / 17-18期

关键词：

Ischemic stroke; TNF-alpha; Ethnic populations; Functional polymorphisms; NECROSIS-FACTOR-ALPHA; CEREBRAL INFARCTION; NITRIC-OXIDE; FOLLOW-UP; DISEASE; ASSOCIATION; CLASSIFICATION; RECEPTORS; INFECTION; HISTORY;

D O I：

10.1016/j.cca.2010.05.007

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Increasing evidences for the role of tumor necrosis factor-alpha (TNF-alpha) in the occurrence of ischemic stroke (IS) have shown that it belongs to pro-inflammatory cytokines and carries functional polymorphisms (TNF-alpha 238G/A and TNF-alpha -308G/A) in its promoter region, which affect their transcription rate and plasma cytokine level. We determined the association between these polymorphisms an the occurrence of IS in the Chinese Han and Uyghur populations. Methods: The TNF-alpha -238G/A and TNF-alpha -308G/A polymorphisms were determined by TagMan SNP Genotyping assays in cases (n = 748) and controls (n = 748). Multivariate logistic r gression analysis was used to show the association between the TNF-alpha genotypes and the IS events. Results: No significant difference was found in the association between TNF-alpha -238G/A and IS in both ethnic populations. The result showed that carriage of the INF-alpha 308GA was a decreased risk of IS in both Han and Uyghur populations (OR:0.453,0.213). In addition, the significant difference in GA frequency in TNF-alpha was found between the two ethnic controls (P= 0.000). Conclusions: TNF-alpha 308 GA heterozygous may bean independent protective facto: for IS in the Chinese Han and Uyghur populations. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1291 / 1295

页数：5

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