Reduced neutron production through use of a flattening-filter-free accelerator

Purpose: To measure and compare neutron fluence around an accelerator operating at 18 MV, both with the flattening filter present (FF mode) and absent (flattening-filter-free [FFF] mode). Methods and Materials: The neutron fluence was measured at several locations in the patient plane using gold foil activation in-neutron moderators. Differences in neutron fluence between the FF and FFF mode were assessed in three frameworks: (1) measured per monitor unit of machine-on time, (2) determined per dose on the central axis, and (3) determined for a complete course of prostate intensity-modulated radiotherapy. Results: Neutron fluence per monitor unit was approximately 20% lower when the accelerator was operated in the FFF mode than when it was in FF mode. The total amount of neutron fluence that would be obtained during the entire course of prostate intensity-modulate radiotherapy was 69% lower when the accelerator was operated in the FFF mode than when it was in the FF mode. This reduction in neutron fluence would correspond to a drastic reduction in the neutron dose equivalent received by the patient as a byproduct of high-energy radiotherapy. It would also correspond to a reduction in activation within the treatment vault and subsequent exposure to radiation therapists. Conclusion: When feasible, operating the accelerator without a FF will benefit both patients and radiation therapists by reducing the number of unwanted neutrons and resultant exposure. This reduces the risk of negative effects from such exposure (e.g., second cancers). (C) 2007 Elsevier Inc.