Disruption of neuronal calcium homeostasis after chronic aluminium toxicity in rats

被引：31
作者：
Kaur, A [1 ]
Gill, KD [1 ]
机构：
[1] Postgrad Inst Med Educ & Res, Dept Biochem, Chandigarh 160012, India
来源：
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY | 2005年 / 96卷 / 02期
关键词：
D O I：
10.1111/j.1742-7843.2005.pto960205.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study was designed to investigate the possible effects of chronic aluminium exposure on the various aspects of calcium homeostasis in rat brain. Chronic aluminium administration caused significant rise in the intrasynaptosomal calcium levels. The activity of major calcium-expelling enzyme, i.e. Ca2+ ATPase was found to be lowered. Also, the calcium uptake via voltage-operated calcium channels increased significantly. Similar to the increase in intrasynaptosomal calcium, calpain activity was found to be increased. The results presented here, indicate that the toxic effects of aluminium could be mediated through modifications in the intracellular calcium homeostasis, which may lead to impaired neuronal function.
引用
收藏
页码：118 / 122
页数：5
相关论文
共 35 条
[1]   Neuropathology of aluminum toxicity in rats (glutamate and GABA impairment) [J].
Abd El-Rahman, SS .
PHARMACOLOGICAL RESEARCH, 2003, 47 (03) :189-194
[2]   INTRASYNAPTOSOMAL FREE CALCIUM-CONCENTRATION IS INCREASED BY PHORBOL ESTERS VIA A 1,4-DIHYDROPYRIDINE-SENSITIVE (L-TYPE) CA-2+ CHANNEL [J].
ADAMSON, P ;
HAJIMOHAMADREZA, I ;
BRAMMER, MJ ;
CAMPBELL, IC .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 162 (01) :59-66
[3]  
ANGHILERI LJ, 1992, NEUROTOXICOLOGY, V13, P475
[4]   Differential toxicity of nitric oxide, aluminum, and amyloid β-peptide in SN56 cholinergic cells from mouse septum [J].
Bielarczyk, H ;
Jankowska, A ;
Madziar, B ;
Matecki, A ;
Michno, A ;
Szutowicz, A .
NEUROCHEMISTRY INTERNATIONAL, 2003, 42 (04) :323-331
[5]   NEUROTOXIC EFFECT OF ENTERAL ALUMINUM [J].
BILKEIGORZO, A .
FOOD AND CHEMICAL TOXICOLOGY, 1993, 31 (05) :357-361
[6]   A COOMASSIE BRILLIANT BLUE G-250-BASED COLORIMETRIC ASSAY FOR MEASURING ACTIVITY OF CALPAIN AND OTHER PROTEASES [J].
BUROKERKILGORE, M ;
WANG, KKW .
ANALYTICAL BIOCHEMISTRY, 1993, 208 (02) :387-392
[7]   GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM [J].
CHOI, DW .
NEURON, 1988, 1 (08) :623-634
[8]   EFFECT OF MONO-VALENT CATIONS ON NA+/CA-2+ EXCHANGE AND ATP-DEPENDENT CA-2+ TRANSPORT IN SYNAPTIC PLASMA-MEMBRANES [J].
COUTINHO, OP ;
CARVALHO, AP ;
CARVALHO, CAM .
JOURNAL OF NEUROCHEMISTRY, 1983, 41 (03) :670-676
[9]   Effect of long-term aluminum feeding on kinetics attributes of tissue cholinesterases [J].
Dave, KR ;
Syal, AR ;
Katyare, SS .
BRAIN RESEARCH BULLETIN, 2002, 58 (02) :225-233
[10]   CHLORDECONE INHIBITION OF CALMODULIN ACTIVATED CALCIUM ATPASE IN RAT-BRAIN SYNAPTOSOMES [J].
DESAIAH, D ;
CHETTY, CS ;
RAO, KSP .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1985, 16 (02) :189-195
1234