The effect of the preservative methylparaben on the thermoresponsive gelation behavior of aqueous solutions of poloxamer 407

被引：22
作者：
Boonlai, Wannisa [1 ]
Tantishaiyakul, Vimon [2 ,3 ]
Hirun, Namon [1 ,4 ]
Phaisan, Suppalak [1 ]
Uma, Thitima [1 ]
机构：
[1] Walailak Univ, Sch Pharm, Nakhon Si Thammarat 80161, Thailand
[2] Prince Songkla Univ, Ctr Excellence Drug Delivery Syst, Hat Yai 90112, Thailand
[3] Prince Songkla Univ, Dept Pharmaceut Chem, Fac Pharmaceut Sci, Hat Yai 90112, Thailand
[4] Walailak Univ, Sch Sci, Theoret & Computat Modeling Res Unit, Nakhon Si Thammarat 80161, Thailand
来源：
JOURNAL OF MOLECULAR LIQUIDS | 2017年 / 240卷
关键词：
Poloxamer; 407; Methylparaben; Micelles; Thermoresponsive gelation; PEO-PPO-PEO; IN-SITU GEL; RHEOLOGICAL PROPERTIES; TRIBLOCK COPOLYMER; DRUG-DELIVERY; MICELLIZATION; WATER; METHYLCELLULOSE; SURFACTANT; HYDROGEL;
D O I：
10.1016/j.molliq.2017.05.120
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The effects of 0.2% (w/v) methylparaben (0.2MP) on the micellization, intermicellar association and gelation characteristics of poloxamer 407 (PX) in aqueous solution as well as the water distribution in PX based samples have been investigated. Differential scanning calorimetry (DSC) studies demonstrated that 0.2MP shifted the critical micellization temperature (CMT) of PX to a lower temperature. According to sub-ambient DSC determination, 0.2MP disturbed interfacial water surrounding PX and decreased CMT. Flow curves revealed that intermicellar association of PX was promoted by 0.2MP. Since more intermicellar packing facilitated the thermoresponsive gelation, the reduction of the sol-gel transition temperature of PX was also substantiated in the presence of 0.2MP as indicated by temperature sweep tests. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：622 / 629
页数：8
相关论文
共 55 条
  • [1] In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery
    Al Khateb, Kosai
    Ozhmukhametova, Elvira K.
    Mussin, Marat N.
    Seilkhanov, Serzhan K.
    Rakhypbekov, Tolebai K.
    Lau, Wing Man
    Khutoryanskiy, Vitaliy V.
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 502 (1-2) : 70 - 79
  • [2] Allen L.V., 2008, ART SCI TECHNOLOGY P
  • [3] Ashraf S, 2016, MACROMOL RES, V24, P297
  • [4] Synergistic effect of salt mixture on the gelation temperature and morphology of methylcellulose hydrogel
    Bain, Mrinal Kanti
    Bhowmick, Biplab
    Maity, Dipanwita
    Mondal, Dibyendu
    Mollick, Md Masud Rahaman
    Rana, Dipak
    Chattopadhyay, Dipankar
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2012, 51 (05) : 831 - 836
  • [5] Effect of laponite clay particles on thermal and rheological properties of Pluronic triblock copolymer
    Boucenna, Imane
    Royon, L.
    Colinart, P.
    [J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2009, 98 (01) : 119 - 123
  • [6] Rheological Behavior and Structure of a Commercial Esterquat Surfactant Aqueous System
    Calero, Nuria
    Carmen Alfaro, Ma
    Angeles Lluch, Ma
    Berjano, Manuel
    Munoz, Jose
    [J]. CHEMICAL ENGINEERING & TECHNOLOGY, 2010, 33 (03) : 481 - 488
  • [7] STATE OF WATER AND SURFACTANT IN LYOTROPIC LIQUID-CRYSTALS
    CASILLAS, N
    PUIG, JE
    OLAYO, R
    HART, TJ
    FRANSES, EI
    [J]. LANGMUIR, 1989, 5 (02) : 384 - 389
  • [8] Chhabra RP, 2008, NON-NEWTONIAN FLOW AND APPLIED RHEOLOGY: ENGINEERING APPLICATIONS, 2ND EDITION, P1
  • [9] Ezrahi S., 2002, ADSORPTION AGGREGATI, P105
  • [10] Faroongsarng D, 2009, CHEM ENG METHOD TECH, P573
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