Does peripheral neuropathy invariably accompany nephropathy in type I diabetes mellitus?

被引:11
作者
Shaw, JE
Gokal, R
Hollis, S
Boulton, AJM
机构
[1] Manchester Royal Infirm, Dept Med, Manchester M13 9WL, Lancs, England
[2] Manchester Royal Infirm, Dept Renal Med, Manchester M13 9WL, Lancs, England
[3] Univ Lancaster, Med Stat Unit, Lancaster, England
关键词
diabetic neuropathy; diabetic nephropathy; diabetes mellitus; renal transplantation;
D O I
10.1016/S0168-8227(97)00122-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In patients with Type 1 diabetes mellitus complicated by diabetic nephropathy and retinopathy, it is usually believed that significant neuropathy is almost universal, but few studies have directly addressed this. This study assessed neuropathy in 91 such subjects, using vibration perception thresholds (VPT) and the neuropathy disability score (NDS). A total of 34% of subjects had no neuropathy on age adjusted VPT (z score) and 26% had no neuropathy on NDS. The severity of neuropathy as measured by VPT z score was related to increasing glycated haemoglobin (P = 0.02) and male sex (P = 0.03), and NDS was independently associated with age (P < 0.0001) and HbA(1c) (P = 0.003). These factors together accounted for only 12 and 31% of the total variance in VPT z score and NDS, respectively. In conclusion, the study has shown that a significant proportion of patients with diabetic nephropathy are free of neuropathy, but the full explanation for their protection from neuropathy is unclear. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:55 / 61
页数:7
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