The Form and Function of PIEZO2

被引:75
作者
Szczot, Marcin [1 ,2 ]
Nickolls, Alec R. [1 ]
Lam, Ruby M. [1 ,3 ]
Chesler, Alexander T. [1 ,4 ]
机构
[1] NIH, Natl Ctr Complementary & Integrat Hlth, Bethesda, MD 20892 USA
[2] Linkoping Univ, Dept Clin & Expt Med, Ctr Social & Affect Neurosci, S-58330 Linkoping, Sweden
[3] Brown Univ, NIH, Grad Program Neurosci, Providence, RI 02912 USA
[4] NINDS, NIH, Bethesda, MD 20892 USA
来源
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021 | 2021年 / 90卷
基金
美国国家卫生研究院;
关键词
PIEZO2; mechanosensation; mechanotransduction; somatosensation; touch; proprioception; ion channel; ACTIVATED ION-CHANNEL; VAGAL SENSORY NEURONS; MERKEL CELLS; DISTAL ARTHROGRYPOSIS; MECHANOTRANSDUCTION CHANNEL; CUTANEOUS RECEPTORS; INFLAMMATORY PAIN; TOUCH SENSATION; GENETIC-CONTROL; GORDON SYNDROME;
D O I
10.1146/annurev-biochem-081720-023244
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mechanosensation is the ability to detect dynamic mechanical stimuli (e.g., pressure, stretch, and shear stress) and is essential for a wide variety of processes, including our sense of touch on the skin. How touch is detected and transduced at the molecular level has proved to be one of the great mysteries of sensory biology. A major breakthrough occurred in 2010 with the discovery of a family of mechanically gated ion channels that were coined PIEZOs. The last 10 years of investigation have provided a wealth of information about the functional roles and mechanisms of these molecules. Here we focus on PIEZO2, one of the two PIEZO proteins found in humans and other mammals. We review how work at the molecular, cellular, and systems levels over the past decade has transformed our understanding of touch and led to unexpected insights into other types of mechanosensation beyond the skin.
引用
收藏
页码:507 / 534
页数:28
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