Aberrant regional homogeneity in post-traumatic stress disorder after traffic accident: A resting-state functional MRI study

被引：11

作者：

Fu, Shishun ^{[1
]}

Ma, Xiaofen ^{[2
]}

Li, Changhong ^{[2
]}

Wang, Tianyue ^{[2
]}

Li, Chao ^{[4
]}

Bai, Zhigang ^{[3
]}

Hua, Kelei ^{[1
,2
]}

Yin, Yi ^{[1
,2
]}

Wu, Yunfan ^{[1
,2
]}

Yu, Kanghui ^{[1
,2
]}

Liu, Mengchen ^{[1
]}

Ke, Qiying ^{[1
]}

Tian, Junzhang ^{[1
,2
]}

Jiang, Guihua ^{[1
,2
]}

机构：

[1] Southern Med Univ, Sch Clin Med 2, Guangzhou, Guangdong, Peoples R China

[2] Southern Med Univ, Guangdong Prov Gen Hosp 2, Dept Med Imaging, Guangzhou, Guangdong, Peoples R China

[3] Inner Mongolia Med Univ, Affiliated Hosp, Hohhot, Peoples R China

[4] China Med Univ, Affiliated Hosp 1, Taichung, Taiwan

来源：

NEUROIMAGE-CLINICAL | 2019年 / 24卷

基金：

中国国家自然科学基金;

关键词：

PTSD; Angular gyms; fMRI; Traffic accidents; MODE NETWORK CONNECTIVITY; BRAIN ACTIVITY; METAANALYSIS; CORTEX; PERFUSION; SYMPTOMS; AMYGDALA; GROWTH; VOLUME; FMRI;

D O I：

10.1016/j.nicl.2019.101951

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Objectives: The present study explored the changes in spontaneous regional activity in post-traumatic stress disorder (PTSD) patients, who experienced severe traffic accidents. Methods: 20 drug-naive PTSD patients and 18 healthy control subjects were imaged using resting-state functional magnetic resonance imaging (rs-fMRI) and analyzed by the algorithm of regional homogeneity (ReHo). Results: Compared to the healthy control group, the PTSD group showed decreased ReHo values in the right angular gyrus. In addition, a negative correlation was found between the activity level of the angular gyrus and the CAPS score. Conclusion: The dysfunctions were found in the memory- and emotion-related areas, suggested a possible mechanism of memory dysregulation that might be related to the intrusive memory symptoms of PTSD. These results provided imaging evidence that might provide an in-depth understanding of the intrinsic functional architecture of PTSD.

引用

页数：6

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