TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

被引：772
作者：
Yang, Li [1 ]
Pang, Yanli [1 ]
Moses, Harold L. [2 ]
机构：
[1] NCI, Lab Canc Biol & Genet, Ctr Canc Res, NIH, Bethesda, MD 20876 USA
[2] Vanderbilt Univ, Sch Med, Dept Canc Biol, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA
来源：
TRENDS IN IMMUNOLOGY | 2010年 / 31卷 / 06期
关键词：
GROWTH-FACTOR-BETA; NF-KAPPA-B; T-CELLS; MYELOID CELLS; COLON-CANCER; PROMOTE METASTASIS; LUNG METASTASIS; BREAST-CANCER; IN-VIVO; INFLAMMATION;
D O I：
10.1016/j.it.2010.04.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Transforming growth factor beta (TGF-beta) plays an important role in tumor initiation and progression, functioning as both a suppressor and a promoter. The mechanisms underlying this dual role of TGF-beta remain unclear. TGF-beta exerts systemic immune suppression and inhibits host immunosurveillance. Neutralizing TGF-beta enhances CD8+ T-cell- and NK-cell-mediated anti-tumor immune responses. It also increases neutrophil-attracting chemokines resulting in recruitment and activation of neutrophils with an antitumor phenotype. In addition to its systemic effects, TGF-beta regulates infiltration of inflammatory/immune cells and cancer-associated fibroblasts in the tumor miwcroenvironment causing direct changes in tumor cells. Understanding TGF-beta regulation at the interface of tumor and host immunity should provide insights into developing effective TGF-beta antagonists and biomarkers for patient selection and efficacy of TGF-beta antagonist treatment.
引用
收藏
页码：220 / 227
页数：8
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