Vaginal epidermal dendritic cells: defense against HIV-1 or a safe haven?

被引:1
|
作者
Caucheteux, Stephan [1 ]
Piguet, Vincent [1 ,2 ]
机构
[1] Univ Toronto, Dept Med, Div Dermatol, Toronto, ON, Canada
[2] Womens Coll Hosp, Div Dermatol, Toronto, ON, Canada
来源
JOURNAL OF CLINICAL INVESTIGATION | 2018年 / 128卷 / 08期
关键词
PREEXPOSURE PROPHYLAXIS; INFECTION; INNATE; TRANSMISSION; RESTRICTION; HEALTH;
D O I
10.1172/JCI121744
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Langerhans cells (LCs) are likely among the first targets of HIV-1 infection due to their localization in mucosal tissues. In their recent work, Pena-Cruz and colleagues were able to study HIV-1 infection in vaginal epithelial DCs (VEDCs), termed CD1a(+) VEDCs. They show that VEDCs are distinct from other blood- and tissue-derived DCs or LCs because they express the protein langerin but not the lectin receptor DC-SIGN, and they do not have Birbeck granules. The results from this study indicate that HIV-1 using CXCR4 replicates poorly in VEDCs but that a higher replication for HIV-1 using CCR5 strains is supported by VDECs. Furthermore, Pena-Cruz and colleagues demonstrate that VDECs can represent a viral reservoir in HIV-1-infected virologically suppressed women. As such, VDECs may represent another sanctuary of viral persistence and can be an additional obstacle to viral eradication.
引用
收藏
页码:3228 / 3230
页数:3
相关论文
共 50 条
  • [1] EPIDERMAL AND MUCOSAL DENDRITIC CELLS AND HIV-1 INFECTION
    SCHMITT, D
    DEZUTTERDAMBUYANT, C
    PATHOLOGY RESEARCH AND PRACTICE, 1994, 190 (9-10) : 955 - 959
  • [2] Vaginal Myeloid Dendritic Cells Transmit Founder HIV-1
    Shen, Ruizhong
    Kappes, John C.
    Smythies, Lesley E.
    Richter, Holly E.
    Novak, Lea
    Smith, Phillip D.
    JOURNAL OF VIROLOGY, 2014, 88 (13) : 7683 - 7688
  • [3] HIV-1 replicates and persists in vaginal epithelial dendritic cells
    Pena-Cruz, Victor
    Agosto, Luis M.
    Akiyama, Hisashi
    Olson, Alex
    Moreau, Yvetane
    Larrieux, Jean-Robert
    Henderson, Andrew
    Gummuluru, Suryaram
    Sagar, Manish
    JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (08): : 3439 - 3444
  • [4] Dendritic Cells, the Double Agent in the War Against HIV-1
    Martin-Moreno, Alba
    Angeles Munoz-Fernandez, Ma
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [5] Dendritic cells in HIV-1 infection
    Spetz, Anna-Lena
    INDIAN JOURNAL OF VIROLOGY, 2008, 19 (01): : 81 - 81
  • [6] Dendritic cells and transmission of HIV-1
    Sewell, AK
    Price, DA
    TRENDS IN IMMUNOLOGY, 2001, 22 (04) : 173 - 175
  • [7] Dendritic cells and the replication of HIV-1
    Cameron, P
    Pope, M
    GranelliPiperno, A
    Steinman, RM
    JOURNAL OF LEUKOCYTE BIOLOGY, 1996, 59 (02) : 158 - 171
  • [8] Lactoferrin nanoparticles coencapsulated with curcumin and tenofovir improve vaginal defense against HIV-1 infection
    Yeruva, Samrajya Lakshmi
    Kumar, Prashant
    Deepa, Seetharam
    Kondapi, Anand K.
    NANOMEDICINE, 2021, 16 (07) : 569 - +
  • [9] HIV-1 selection by epidermal dendritic cells during transmission across human skin
    Reece, JC
    Handley, AJ
    Anstee, EJ
    Morrison, WA
    Crowe, SM
    Cameron, PU
    JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (10): : 1623 - 1631
  • [10] EPIDERMAL LANGERHANS CELLS AND HIV-1 INFECTION
    DEZUTTERDAMBUYANT, C
    SCHMITT, D
    IMMUNOLOGY LETTERS, 1993, 39 (01) : 33 - 37