The Predicted Long-Term Benefits of Ensuring Timely Treatment and Medication Adherence in Early Schizophrenia

被引:7
作者
Horvitz-Lennon, Marcela [1 ]
Predmore, Zachary [1 ,3 ]
Orr, Patrick [1 ,5 ]
Hanson, Mark [2 ,4 ]
Hillestad, Richard [2 ]
Durkin, Mike [6 ]
El Khoury, Antoine C. [6 ]
Mattke, Soeren [1 ,4 ]
机构
[1] RAND Corp, 20 Pk Plaza,Suite 920, Boston, MA 02116 USA
[2] RAND Corp, Santa Monica, CA USA
[3] Johns Hopkins Univ, Baltimore, MD USA
[4] Univ Southern Calif, Los Angeles, CA 90007 USA
[5] Informat Mapping, Boston, MA USA
[6] Janssen Sci Affairs LLC, Titusville, NJ USA
关键词
Schizophrenia; Treatment adherence; Early detection; Simulation; QUALITY-OF-LIFE; UNTREATED PSYCHOSIS; 1ST-EPISODE SCHIZOPHRENIA; EARLY INTERVENTION; NEGATIVE SYMPTOMS; MENTAL-ILLNESS; UNITED-STATES; DURATION; DISORDERS; PEOPLE;
D O I
10.1007/s10488-019-00990-7
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
The impact of initiatives aimed at reducing time in untreated psychosis during early-stage schizophrenia will be unknown for many years. Thus, we simulate the effect of earlier treatment entry and better antipsychotic drug adherence on schizophrenia-related hospitalizations, receipt of disability benefits, competitive employment, and independent/family living over a ten-year horizon. We predict that earlier treatment entry reduces hospitalizations by 12.6-14.4% and benefit receipt by 7.0-8.5%, while increasing independent/family living by 41.5-46% and employment by 42-58%. We predict larger gains if a pro-adherence intervention is also used. Our findings suggest substantial benefits of timely and consistent early schizophrenia care.
引用
收藏
页码:357 / 365
页数:9
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