Hedychium coronarium Rhizomes: Promising Antidiabetic and Natural Inhibitor of α-Amylase and α-Glucosidase

被引：19

作者：

Panigrahy, Suchitra K. ^{[1
]}

Kumar, Awanish ^{[2
]}

Bhatt, Renu ^{[1
]}

机构：

[1] Guru Ghasidas Vishwavidyalaya, Dept Biotechnol, Bilaspur 495009, Chhattisgarh, India

[2] NIT, Dept Biotechnol, Raipur 492010, Chhattisgarh, India

来源：

JOURNAL OF DIETARY SUPPLEMENTS | 2020年 / 17卷 / 01期

关键词：

alpha-amylase; alpha-glucosidase; Hedychium coronarium; HRLC-MS; MS; terpene; EXTRACT;

D O I：

10.1080/19390211.2018.1483462

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Hedychium coronarium Koen., commonly known as ginger lily, is considered an endemic medicinal plant. In the present study, the antidiabetic action of its rhizomes was investigated by alpha-amylase and alpha-glucosidase inhibition assay, and the active compounds were identified through bioactivity guided isolation technique. Among the six different extracts, the EA extract has shown highest inhibition, and the subfractions from active EA extract were separated by silica gel column chromatography. The subfraction showing highest inhibition was investigated for its chemical composition by high-resolution liquid chromatography-mass spectroscopy (HRLC-MS/MS). The fatty acids such as suberic acid and terpenes such as triparanol, ginkgolide C, and swietenine were found to be the major compounds in the subfractions. The present work revealed that H. coronarium rhizome extract and its active constituent could be used as a natural inhibitor of these two carbohydrate-metabolizing enzymes and may play a key role in the management of diabetes.

引用

页码：81 / 87

页数：7

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