The interplay between microRNAs and Twist1 transcription factor: a systematic review

被引：30

作者：

Khanbabaei, Hashem ^{[1
]}

Teimoori, Ali ^{[2
]}

Mohammadi, Milad ^{[3
]}

机构：

[1] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Med Phys, Radiobiol Lab, Ahvaz, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Hlth Res Inst, Infect & Trop Dis Res Ctr, Ahvaz, Iran

[3] Univ Hosp Wurzburg, Dept Anesthesiol, Wurzburg, Germany

来源：

TUMOR BIOLOGY | 2016年 / 37卷 / 06期

关键词：

Twist1; microRNAs; Epithelial mesenchymal transition; Cancer; Metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; CANCER STEM-CELLS; E1A GENE-THERAPY; BREAST-CANCER; SIGNALING PATHWAYS; DOWN-REGULATION; TUMOR INVASION; CLINICAL-TRIAL; UP-REGULATION; PROMOTES EMT;

D O I：

10.1007/s13277-016-4960-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twist1 (also known as Twist) is a transcription factor that belongs to the family of basic helix-loop-helix (bHLH) proteins. It functions as a negative regulator of epithelial gene expression and a positive regulator of mesenchymal gene expression, thereby leading to induction of the epithelial mesenchymal transition (EMT), a process in which epithelial cells acquire the motile and migratory characteristics of mesenchymal cells. In addition to regulating the expression of protein-coding genes, Twist1 regulates the expression of microRNAs (miRNAs), adding a regulatory layer to EMT induction. Interestingly, the mRNA of Twist1 represents a downstream target of miRNAs, indicating an intricate network between miRNAs and Twist1. This network was shown to play multiple roles in cancer cell migration, invasion, and metastasis. The network can induce angiogenesis, protect cells from oncogene-induced apoptosis and senescence, enhance cancer cell resistance to conventional therapies, and increase cancer stem cell (CSC) populations. Recently, miRNAs have attracted considerable attention as potential promising tools in cancer therapies. Thus, this systematic review was conducted to clarify the reciprocal link between Twist1 and miRNAs in order to provide potential candidate miRNAs for diagnostic and therapeutic approaches in cancer treatment.

引用

页码：7007 / 7019

页数：13

共 96 条

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