The inverse of immunity

被引：18

作者：

Dolgin, Elie

机构：

[1] Elie Dolgin is Nature Medicine's assistant news editor in New York.,

来源：

NATURE MEDICINE | 2010年 / 16卷 / 07期

关键词：

MYELIN BASIC-PROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS; CEREBROSPINAL-FLUID; CLINICAL-TRIAL; PEPTIDE; INHIBITION; AFFINITY;

D O I：

10.1038/nm0710-740

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ever since Edward Jenner discovered the smallpox vaccine two centuries ago, immunization efforts have almost exclusively focused on activating the immune system. But when it comes to multiple sclerosis and other autoimmune disorders, researchers hope to switch off-rather than ramp up-the body's defenses. Even an automotive service mogul has taken the idea on board. Elie Dolgin investigates how the idea of vaccination is being turned on its head.

引用

收藏

页码：740 / 743

页数：4

相关论文

共 12 条

[1] Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand [J].

Bielekova, B ;

Goodwin, B ;

Richert, N ;

Cortese, I ;

Kondo, T ;

Afshar, G ;

Gran, B ;

Eaton, J ;

Antel, J ;

Frank, JA ;

McFarland, HF ;

Martin, R .

NATURE MEDICINE, 2000, 6 (10) :1167-1175

[2] Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis [J].

Garren, Hideki ;

Robinson, William H. ;

Krasulova, Eva ;

Havrdova, Eva ;

Nadj, Congor ;

Selmaj, Krzysztof ;

Losy, Jacek ;

Nadj, Ilinka ;

Radue, Ernst-Wilhelm ;

Kidd, Brian A. ;

Gianettoni, Jill ;

Tersini, Karen ;

Utz, Paul J. ;

Valone, Frank ;

Steinman, Lawrence .

ANNALS OF NEUROLOGY, 2008, 63 (05) :611-620

[3]

KENNEDY MK, 1990, J IMMUNOL, V144, P909

[4] INHIBITION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY INHALATION BUT NOT ORAL-ADMINISTRATION OF THE ENCEPHALITOGENIC PEPTIDE - INFLUENCE OF MHC BINDING-AFFINITY [J].

METZLER, B ;

WRAITH, DC .

INTERNATIONAL IMMUNOLOGY, 1993, 5 (09) :1159-1165

[5] Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions [J].

O'Connor, KC ;

Chitnis, T ;

Griffin, DE ;

Piyasirisilp, S ;

Bar-Or, A ;

Khoury, S ;

Wucherpfennig, KW ;

Hafler, DA .

JOURNAL OF NEUROIMMUNOLOGY, 2003, 136 (1-2) :140-148

[6] T-CELL RECOGNITION OF AN IMMUNODOMINANT MYELIN BASIC-PROTEIN EPITOPE IN MULTIPLE-SCLEROSIS [J].

OTA, K ;

MATSUI, M ;

MILFORD, EL ;

MACKIN, GA ;

WEINER, HL ;

HAFLER, DA .

NATURE, 1990, 346 (6280) :183-187

[7] Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis [J].

Robinson, WH ;

Fontoura, P ;

Lee, BJ ;

de Vegvar, HEN ;

Tom, J ;

Pedotti, R ;

DiGennaro, CD ;

Mitchell, DJ ;

Fong, D ;

Ho, PPK ;

Ruiz, PJ ;

Maverakis, E ;

Stevens, DB ;

Bernard, CCA ;

Martin, R ;

Kuchroo, VK ;

van Noort, JM ;

Genain, CP ;

Amor, S ;

Olsson, T ;

Utz, PJ ;

Garren, H ;

Steinman, L .

NATURE BIOTECHNOLOGY, 2003, 21 (09) :1033-1039

[8]

Steinman L, 2010, J INTERN MED, V267, P441, DOI 10.1111/j.1365-2796.2010.02224.x

[9] Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II-defined cohort of patients with progressive multiple sclerosis: results of a 24-month double-blind placebo-controlled clinical trial and 5 years of follow-up treatment [J].

Warren, K. G. ;

Catz, I. ;

Ferenczi, L. Z. ;

Krantz, M. J. .

EUROPEAN JOURNAL OF NEUROLOGY, 2006, 13 (08) :887-895

[10] INCREASED SYNTHETIC PEPTIDE SPECIFICITY OF TISSUE-CSF BOUND ANTI-MBP IN MULTIPLE-SCLEROSIS [J].

WARREN, KG ;

CATZ, I .

JOURNAL OF NEUROIMMUNOLOGY, 1993, 43 (1-2) :87-96