Nivolumab monotherapy after induction chemotherapy, bioradiotherapy, and cetuximab monotherapy leading to complete remission of locoregional advanced tongue cancer: A case report

被引:3
|
作者
Yoshioka, Yukio [1 ]
Hamana, Tomoaki [1 ]
Mishima, Takefumi [2 ]
Tani, Ryouji [2 ]
Toratani, Shigeaki [1 ]
Okamoto, Tetsuji [1 ,3 ]
机构
[1] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Mol Oral Med & Maxillofacial Surg, Hiroshima, Japan
[2] Hiroshima Univ Hosp, Dept Oral & Maxillofacial Surg, Hiroshima, Japan
[3] Univ East Asia, Sch Med Sci, Shimonoseki, Yamaguchi, Japan
关键词
Cetuximab; induction chemotherapy; nivolumab; tongue neoplasms; SQUAMOUS-CELL CARCINOMA; HEAD; RECURRENT;
D O I
10.1002/osi2.1114
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Herein, we report on a 66-year-old woman with locoregional advanced tongue cancer. She was diagnosed with left side tongue carcinoma and achieved complete remission using nivolumab monotherapy after induction chemotherapy (IC) with docetaxel, cisplatin, and 5-fluorouracil, followed by intensity-modulated bioradiotherapy and cetuximab monotherapy. Following bioradiotherapy, she was administered 70 cycles of cetuximab monotherapy. Both IC and bioradiotherapy exerted antitumor effects. However, primary tumor recurrence occurred. She received nivolumab, and the recurrent lesion disappeared after 18 cycles. She has been alive and well for >5 years, showing a successful locoregional control for advanced tongue cancer during this period.
引用
收藏
页码:72 / 76
页数:5
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