NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells

被引：97

作者：

Gupta, Rajeev ^{[1
]}

Hong, Dengli ^{[1
]}

Iborra, Francisco ^{[1
]}

Sarno, Samantha ^{[1
]}

Enver, Tariq ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, MRC Mol Haematol Unit, Headington OX3 9DS, England

来源：

SCIENCE | 2007年 / 316卷 / 5824期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1126/science.1136031

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Clinically successful hematopoietic cell transplantation is dependent on hematopoietic stem and progenitor cells. Here we identify the matricellular protein Nephroblastoma Overexpressed (Nov, CCN3) as being essential for their functional integrity. Nov expression is restricted to the primitive (CD34) compartments of umbilical vein cord blood, and its knockdown in these cells by lentivirus-mediated RNA interference abrogates their function in vitro and in vivo. Conversely, forced expression of Nov and addition of recombinant Nov protein both enhance primitive stem and/or progenitor activity. Taken together, our results identify Nov ( CCN3) as a regulator of human hematopoietic stem or progenitor cells.

引用

页码：590 / 593

页数：4

共 31 条

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