Autophagosome formation in mammalian cells

被引：761
作者：
Mizushima, N
Ohsumi, Y
Yoshimori, T
机构：
[1] Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi 4448585, Japan
[2] Japan Sci & Technol Corp, PRESTO, Kawaguchi 3320012, Japan
[3] Natl Inst Genet, Dept Cell Genet, Mishima, Shizuoka 4118540, Japan
来源：
CELL STRUCTURE AND FUNCTION | 2002年 / 27卷 / 06期
关键词：
autophagy; autophagosome; Apg12; Apg5; LC3;
D O I：
10.1247/csf.27.421
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Macroautophagy is an intracellular degradation system for the majority of proteins and some organelles. The molecular mechanism of autophagy has been extensively studied using the yeast, Saccharomyces cerevisiae, during these past 10 years. These studies suggested that the molecular machinery of autophagosome formation is well conserved from yeast to higher eukaryotes. Identification and characterization of the mammalian counterparts of the yeast autophagy proteins has facilitated our understanding of mammalian autophagy, particularly of autophagosome formation. These findings are now being applied to studies on the physiological roles of autophagy in mammals.
引用
收藏
页码：421 / 429
页数：9
相关论文
共 83 条
[71]   Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p [J].
Tanida, I ;
Tanida-Miyake, E ;
Komatsu, M ;
Ueno, T ;
Kominami, E .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (16) :13739-13744
[72]   The human homolog of Saccharomyces cerevisiae Apg7p is a protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3 [J].
Tanida, I ;
Tanida-Miyake, E ;
Ueno, T ;
Kominami, E .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (03) :1701-1706
[73]   Retention of mutant α1-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response [J].
Teckman, JH ;
Perlmutter, DH .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2000, 279 (05) :G961-G974
[74]   Fasting in α1-antitrypsin deficient liver:: consultative activation of autophagy [J].
Teckman, JH ;
An, JK ;
Loethen, S ;
Perlmutter, DH .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2002, 283 (05) :G1156-G1165
[75]   ISOLATION OF AUTOPHAGOCYTOSIS MUTANTS OF SACCHAROMYCES-CEREVISIAE [J].
THUMM, M ;
EGNER, R ;
KOCH, B ;
SCHLUMPBERGER, M ;
STRAUB, M ;
VEENHUIS, M ;
WOLF, DH .
FEBS LETTERS, 1994, 349 (02) :275-280
[76]   IN EXOCRINE PANCREAS, THE BASOLATERAL ENDOCYTIC PATHWAY CONVERGES WITH THE AUTOPHAGIC PATHWAY IMMEDIATELY AFTER THE EARLY ENDOSOME [J].
TOOZE, J ;
HOLLINSHEAD, M ;
LUDWIG, T ;
HOWELL, K ;
HOFLACK, B ;
KERN, H .
JOURNAL OF CELL BIOLOGY, 1990, 111 (02) :329-345
[77]   ISOLATION AND CHARACTERIZATION OF AUTOPHAGY-DEFECTIVE MUTANTS OF SACCHAROMYCES-CEREVISIAE [J].
TSUKADA, M ;
OHSUMI, Y .
FEBS LETTERS, 1993, 333 (1-2) :169-174
[78]   GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton [J].
Wang, HB ;
Bedford, FK ;
Brandon, NJ ;
Moss, SJ ;
Olsen, RW .
NATURE, 1999, 397 (6714) :69-72
[79]   Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells [J].
Yamamoto, A ;
Tagawa, Y ;
Yoshimori, T ;
Moriyama, Y ;
Masaki, R ;
Tashiro, Y .
CELL STRUCTURE AND FUNCTION, 1998, 23 (01) :33-42
[80]   CHARACTERIZATION OF THE ISOLATION MEMBRANES AND THE LIMITING MEMBRANES OF AUTOPHAGOSOMES IN RAT HEPATOCYTES BY LECTIN CYTOCHEMISTRY [J].
YAMAMOTO, A ;
MASAKI, R ;
TASHIRO, Y .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1990, 38 (04) :573-580
123456789