Current and Future Oral Systemic Therapies for Psoriasis

被引:28
作者
Kelly, John B., III [1 ]
Foley, Peter [2 ]
Strober, Bruce E. [1 ,3 ]
机构
[1] Univ Connecticut, Ctr Hlth, Dept Dermatol, Farmington, CT 06032 USA
[2] Univ Melbourne, St Vincents Hosp Melbourne, Melbourne, Vic 3010, Australia
[3] Prob Med Res, Waterloo, ON, Canada
关键词
Psoriasis; Methotrexate; Cyclosporine; Acitretin; Apremilast; Tofacitinib; Mycophenolate mofetil; CHRONIC PLAQUE PSORIASIS; RANDOMIZED CONTROLLED-TRIAL; CONTROLLED CLINICAL-TRIAL; PLACEBO-CONTROLLED TRIAL; JANUS KINASE INHIBITOR; FUMARIC-ACID ESTERS; QUALITY-OF-LIFE; RHEUMATOID-ARTHRITIS; DOUBLE-BLIND; MYCOPHENOLATE-MOFETIL;
D O I
10.1016/j.det.2014.09.008
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
For patients with moderate to severe psoriasis, there is a large range of variably effective and safe oral, systemic medications. With appropriate monitoring, these therapies may be used as either monotherapy or in combination with other therapies. Newer drugs in the research pipeline hold significant promise.
引用
收藏
页码:91 / +
页数:20
相关论文
共 73 条
[1]   Efficacy and safety of mycophenolate mofetil vs. methotrexate for the treatment of chronic plaque psoriasis [J].
Akhyani, M. ;
Chams-Davatchi, C. ;
Hemami, M. R. ;
Fateh, S. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2010, 24 (12) :1447-1451
[2]   The use of cyclosporine in dermatology: Part I [J].
Amor, Karrie T. ;
Ryan, Caitriona ;
Menter, Alan .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2010, 63 (06) :925-946
[3]  
[Anonymous], 2014, OT PACK INS
[4]   Fumarates vs. methotrexate in moderate to severe chronic plaque psoriasis: a multicentre prospective randomized controlled clinical trial [J].
Arani, S. Fallah ;
Neumann, H. ;
Hop, W. C. J. ;
Thio, H. B. .
BRITISH JOURNAL OF DERMATOLOGY, 2011, 164 (04) :855-861
[5]   Enteric-coated mycophenolate sodium in psoriasis vulgaris: an open pilot study [J].
Arani, Shiva Fallah ;
Spuij, Rick Waalboer ;
Nijsten, Tamar ;
Neumann, H. A. Martino ;
Thio, Bing .
JOURNAL OF DERMATOLOGICAL TREATMENT, 2014, 25 (01) :46-49
[6]   Pregnancy outcome after cyclosporine therapy during pregnancy: A meta-analysis [J].
Bar-Oz, B ;
Hackman, R ;
Einarson, T ;
Koren, G .
TRANSPLANTATION, 2001, 71 (08) :1051-1055
[7]   Infliximab plus methotrexate is superior to methotrexate alone in the treatment of psoriatic arthritis in methotrexate-naive patients: the RESPOND study [J].
Baranauskaite, Asta ;
Raffayova, Helena ;
Kungurov, N. V. ;
Kubanova, Anna ;
Venalis, Algirdas ;
Helmle, Laszlo ;
Srinivasan, Shankar ;
Nasonov, Evgeny ;
Vastesaeger, Nathan .
ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (04) :541-548
[8]   Efficacy and safety of infliximab vs. methotrexate in patients with moderate-to-severe plaque psoriasis: results of an open-label, active-controlled, randomized trial (RESTORE1) [J].
Barker, J. ;
Hoffmann, M. ;
Wozel, G. ;
Ortonne, J. -P. ;
Zheng, H. ;
van Hoogstraten, H. ;
Reich, K. .
BRITISH JOURNAL OF DERMATOLOGY, 2011, 165 (05) :1109-1117
[9]   Assessment and management of methotrexate hepatotoxicity in psoriasis patients: report from a consensus conference to evaluate current practice and identify key questions toward optimizing methotrexate use in the clinic [J].
Barker, J. ;
Horn, E. J. ;
Lebwohl, M. ;
Warren, R. B. ;
Nast, A. ;
Rosenberg, W. ;
Smith, C. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2011, 25 (07) :758-764
[10]   A Comparison of Mycophenolate Mofetil with Ciclosporine for the Treatment of Chronic Plaque-Type Psoriasis [J].
Beissert, Stefan ;
Pauser, Sylvia ;
Sticherling, Michael ;
Frieling, Uta ;
Loske, Klaus-Dieter ;
Frosch, Peter J. ;
Haase, Ingo ;
Luger, Thomas A. .
DERMATOLOGY, 2009, 219 (02) :126-132