Effectiveness of a 23-valent pneumococcal polysaccharide vaccine for the prevention of pneumococcal pneumonia in the elderly with chronic respiratory diseases: a case-control study of a single center

被引:4
|
作者
Masuda, Toshihiro [1 ]
Nakatani, Eiji [2 ,3 ]
Shirai, Toshihiro [1 ]
Akamatsu, Taisuke [1 ]
Tamura, Kanami [1 ]
Takahashi, Shingo [1 ]
Tanaka, Yuko [1 ]
Watanabe, Hirofumi [1 ]
Endo, Yoshinari [1 ]
Suzuki, Takahito [1 ]
Saigusa, Mika [1 ]
Yamamoto, Akito [1 ]
Morita, Satoru [1 ]
Sato, Yoko [2 ]
Asada, Kazuhiro [1 ]
机构
[1] Shizuoka Prefectural Gen Hosp, Dept Resp Med, Shizuoka, Japan
[2] Shizuoka Prefectural Gen Hosp, Res Support Ctr, Div Clin Biostat, 4-27-1 Kita Ando, Shizuoka 4208527, Japan
[3] Shizuoka Grad Univ Publ Hlth, Grad Sch Publ Hlth, Aoi Ku, 4-27-2 Kitaando, Shizuoka 4200881, Japan
关键词
Chronic respiratory disease; Elderly; Pneumococcal polysaccharide vaccine; Pneumococcus; Pneumonia; Vaccine;
D O I
10.1186/s12890-021-01491-w
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background The effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in preventing pneumococcal pneumonia has been controversial. Methods To evaluate the effectiveness of the PPSV23 in elderly outpatients with chronic respiratory diseases, we carried out a case-control study, including 4128 outpatients aged >= 65 years, in the respiratory department. Results There were 320 vaccinated patients, of which 164 were diagnosed with pneumococcal pneumonia. The adjusted odds ratio was 0.39 (95% confidence interval (CI), 0.17 to 0.89). In the subsets consisting of age groups >= 70 and >= 75 years, the adjusted odds ratio (95% CI) was respectively 0.16 (0.04 to 0.67) and 0.15 (0.02 to 1.12). Conclusion This real-world study suggests that PPSV23 can be useful in preventing pneumococcal pneumonia in the elderly with chronic respiratory diseases.
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页数:6
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