Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study

被引：2

作者：

Pu, Yan ^{[1
]}

Wen, Xu ^{[2
,3
]}

Jia, Zhangjun ^{[3
,4
]}

Xie, Yu ^{[5
]}

Luan, Changxing ^{[6
]}

Yu, Youjia ^{[6
]}

Chen, Feng ^{[6
]}

Chen, Peng ^{[6
]}

Li, Ding ^{[6
]}

Sun, Yan ^{[3
,7
]}

Zhao, Jian ^{[3
,8
]}

Lv, Haiqin ^{[1
]}

机构：

[1] Southeast Univ, Sch Med, Nanjing, Peoples R China

[2] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Canc Hosp, Dept Gen Surg, Nanjing, Peoples R China

[3] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Nanjing, Peoples R China

[4] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Canc Hosp, Dept Clin Lab, Nanjing, Peoples R China

[5] Nanjing Univ, Med Sch, Affiliated Nanjing Drum Tower Hosp, Dept Geriatr, Nanjing, Peoples R China

[6] Nanjing Med Univ, Dept Forens Med, Nanjing, Peoples R China

[7] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Canc Hosp, Dept Med Oncol, Nanjing, Peoples R China

[8] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Canc Hosp, Dept Radiat Oncol, Nanjing, Peoples R China

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2021年 / 8卷

基金：

中国国家自然科学基金;

关键词：

EFNA1; gastric cancer; SNP; case-control; biomarker; PATHWAY ANALYSIS; RECEPTOR; TUMORIGENESIS; ANGIOGENESIS; PROGRESSION; PROMOTES; BINDING; EFNA1;

D O I：

10.3389/fmolb.2021.690665

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastric cancer has the second highest incidence among all the malignancies in China, just below lung cancer. Gastric cancer is likewise one of the main sources of cancer related passings. Gastric cancer therefore remains a huge threat to human health. The primary reason is absence of high sensitivity and specificity for early detection while the pathogenesis of GC is stayed muddled. During the last few decades, a lot of GC related genes have been identified. To find candidate GC related variant in these GC related genes, we conducted this case-control study. 29 tagSNPs located in 7 GC related genes were included. 228 gastric cancer patients and 299 healthy controls were enrolled. Significant differences were found between the genotype frequencies of EFNA1 rs4971066 polymorphism between gastric cancer patients and healthy controls. The result indicated that ephrin-A1 tagSNP rs4971066 GT/TT genotypes was significantly associated with reduced susceptibility of gastric cancer development.

引用

页数：5