Fibrinolytic, anti-inflammatory and anti-microbial properties of α-(1-3)-glucans produced from Streptococcus mutans (MTCC 497)

被引：30
作者：
Buddana, Sudheer Kumar [1 ,2 ]
Varanasi, Yaswanth Venkata Naga [1 ]
Shetty, Prakasham Reddy [1 ,2 ]
机构：
[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India
[2] Acad Sci & Innovat Res, New Delhi, India
来源：
CARBOHYDRATE POLYMERS | 2015年 / 115卷
关键词：
alpha-(1-3)-Glucans; Sulfated alpha-(1-3)-glucans; Antibacterial; Anti-inflammatory; Fibrinolytic; Streptococcus mutans; GLUCAN; PURIFICATION;
D O I：
10.1016/j.carbpol.2014.08.083
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Streptococcus mutans (MTCC 497) cell associated alpha-(1-3)-glucans were isolated, characterized and evaluated for their bioactivity profile. Acid hydrolysis of alpha-(1-3)-glucans revealed presence of glucose moieties. Water insoluble alpha-(1-3)-glucans (WIG) were sulfated to convert them into water soluble glucans which were characterized by FT-IR spectral studies. The sulfation of WIG was confirmed by the presence of -O-SO3- and C-O-SO3- characteristic peaks at 1240 and 820 cm(-1). MALDI-TOF analysis of sulfated alpha-(1-3)-glucan revealed 1.2 to 9 kDa fragmentation. Antibacterial profile studies revealed higher growth inhibitory activity against Gram negative than Gram positive bacterial strains by sulfated alpha-(1-3)-glucans. One-fold higher anti-inflammatory activity with IC50 value of 0.11 mg/ml was observed with sulfated alpha-(1-3)-glucans over WIG. Time dependent fibrinolytic potential without requirement of tissue plasminogen activators was observed for sulfated alpha-(1-3)-glucans. This is the first report demonstrating the fibrinolytic and anti-inflammatory property for sulfated alpha-(1-3)-glucans. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：152 / 159
页数：8
相关论文
共 28 条
  • [21] Exploring 1,3,4-Oxadiazole Scaffold for Anti-inflammatory and Analgesic Activities: A Review of Literature From 2005-2016
    Chawla, Gita
    Naaz, Baby
    Siddiqui, Anees A.
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2018, 18 (03) : 216 - 233
  • [22] Synthesis of Novel Benzodifuranyl; 1,3,5-Triazines; 1,3,5-Oxadiazepines; and Thiazolopyrimidines Derived from Visnaginone and Khellinone as Anti-Inflammatory and Analgesic Agents
    Abu-Hashem, Ameen Ali
    Al-Hussain, Sami A.
    Zaki, Magdi E. A.
    MOLECULES, 2020, 25 (01):
  • [23] Discovery of anti-inflammatory agents from 3, 4-dihydronaphthalene-1 (2H)-one derivatives by inhibiting NLRP3 inflammasome activation
    Li, Wen-Xuan
    Yu, Lu
    Chi, Jiang -Bo
    Wang, Ji-Peng
    Liu, Yong-Jun
    Wang, Chun-Hua
    Zhang, Meng
    Hou, Gui-Ge
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 268
  • [24] DESIGN, SYNTHESIS, CHARACTERIZATION, AND ANTI-MICROBIAL AND INFLAMMATORY ACTIVITY OF NOVEL 3-CHLORO-2-OXO-4-SUBSTITUTED PHENYLAZETIDINONE AND 2-SUBSTITUTED PHENYLTHIAZOLIDINONE-1, 8- NAPHTHALIMIDE DERIVATIVE SPACERS
    Sirgamalla, Rambabu
    Devaram, J.
    Konduru, Sumalatha
    HETEROCYCLIC LETTERS, 2020, 10 (01): : 97 - 107
  • [25] Evaluation of the anti-inflammatory and antioxidant properties and isolation and characterization of a new bioactive compound, 3,4,9-trime- thyl-7-propyldecanoic acid from Vitex negundo
    Sivapalan, Sreewardhini
    Dharmalingam, Sankari
    Ashokkumar, Veeramuthu
    Venkatesan, Vijayalakshmi
    Angappan, Mangalagowri
    JOURNAL OF ETHNOPHARMACOLOGY, 2024, 319
  • [26] Identification of hydroxyquinazoline alkaloids from Justicia adhatoda L. leaves, a traditional natural remedy with NF- κ B and AP-1-mediated anti-inflammatory properties and antioxidant activity
    Peron, Gregorio
    Phuyal, Ganga Prasad
    Hos, Jan
    Adhikari, Rameshwar
    Dall'Acqua, Stefano
    JOURNAL OF ETHNOPHARMACOLOGY, 2024, 331
  • [27] Orthidines A-E, tubastrine, 3,4-dimethoxyphenethyl-β-guanidine, and 1,14-sperminedihomovanillamide:: Potential anti-inflammatory alkaloids isolated from the New Zealand ascidian Aplidium orthium that act as inhibitors of neutrophil respiratory burst
    Pearce, A. Norrie
    Chia, Elizabeth W.
    Berridge, Michael V.
    Maas, Elizabeth W.
    Page, Michael J.
    Harper, Jacquie L.
    Webb, Victoria L.
    Copp, Brent R.
    TETRAHEDRON, 2008, 64 (24) : 5748 - 5755
  • [28] Synthesis, analgesic, anti-inflammatory and ulcerogenic properties of some novel N'-((1-(substituted amino) methyl)-2-oxoindolin-3-ylidene)4-(2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl) benzohydrazide derivatives
    Saravanan, Govindaraj
    Alagarsamy, Veerachamy
    Prakash, Chinnasamy Rajaram
    DRUG DISCOVERIES AND THERAPEUTICS, 2012, 6 (02) : 78 - 87
123