Leptin phase-advances the rat suprachiasmatic circadian clock in vitro

被引：66

作者：

Prosser, RA ^{[1
]}

Bergeron, HE ^{[1
]}

机构：

[1] Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37996 USA

来源：

NEUROSCIENCE LETTERS | 2003年 / 336卷 / 03期

关键词：

circadian rhythms; suprachiasmatic nucleus; leptin; rats; metabolic regulation; brain slices;

D O I：

10.1016/s0304-3940(02)01234-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The suprachiasmatic nucleus (SCN) controls circadian rhythms in mammals. The SCN may also participate in regulating body metabolism and energy. Similar to other hypothalamic nuclei, the SCN have been reported to contain glucose-sensitive neurons and receptors for the adipose tissue hormone, leptin. Here we investigated leptin effects on the SCN clock. Our results demonstrate that the SCN circadian clock, when isolated in vitro, can be phase advanced by leptin in a dose-dependent fashion that does not require non-SCN hypothalamic tissue. Phase advances are induced at all circadian times except late subjective night. These data suggest that peripheral signals of energy and metabolism directly modulate the circadian pacemaker in mammals. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：139 / 142

页数：4

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