Mesoporous silica-coated NaYF4:Yb3+, Er3+ particles for drug release

被引：15

作者：

Kong, Deyan ^{[1
,2
]}

Fan, Yong ^{[1
]}

Zhang, Cuimiao ^{[1
]}

Lin, Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2010年 / 12卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Up-conversion fluorescence; Drug release; Mesoporous silica; Drug delivery; Nanomedicine; SHELL STRUCTURE; DELIVERY; SYSTEM; NANOCOMPOSITE; NANOPARTICLES; FABRICATION; MOLECULES; IBUPROFEN; SURFACE; MCM-41;

D O I：

10.1007/s11051-009-9635-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NaYF4:Yb3+, Er3+ nanoparticles were successfully prepared by a polyol process using diethyleneglycol (DEG) as solvent. These NaYF4:Yb3+, Er3+ nanoparticles can be coated with mesoporous silica using nonionic triblock copolymer EO20PO70 EO20 (P 123) as structure-directing agent and other materials. The composites can load ibuprofen and release the drug in the phosphate buffer solution (PBS). The composites were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption/desorption isotherms, fluorescence spectra, and UV/Vis absorption spectra, respectively. The composites have the mesoporous structure. In addition, the composites emit red fluorescence (from Er3+) under 980 nm near infrared laser excitation, which can be used as fluorescent probes in the drug-delivery system.

引用

页码：663 / 673

页数：11

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