Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

被引：1441

作者：

Dao, Maria Carlota ^{[1
,2
,3
]}

Everard, Amandine ^{[4
]}

Aron-Wisnewsky, Judith ^{[1
,2
,3
]}

Sokolovska, Nataliya ^{[1
,2
,3
]}

Prifti, Edi ^{[1
]}

Verger, Eric O. ^{[1
,2
,3
]}

Kayser, Brandon D. ^{[1
]}

Levenez, Florence ^{[5
,6
]}

Chilloux, Julien ^{[7
]}

Hoyles, Lesley ^{[7
]}

Dumas, Marc-Emmanuel ^{[7
]}

Rizkalla, Salwa W. ^{[1
]}

Dore, Joel ^{[5
,6
]}

Cani, Patrice D. ^{[4
]}

Clement, Karine ^{[1
,2
,3
]}

机构：

[1] Hop La Pitie Salpetriere, Assistance Publ Hop Paris, ICAN, Inst Cardiometab & Nutr, Paris, France

[2] INSERM, UMR S U1166, Nutriom Team, Paris, France

[3] Univ Paris 06, Sorbonne Univ, UMR S 1166 1, Nutriom Team, Paris, France

[4] Catholic Univ Louvain, Metab & Nutr Res Grp, Louvain Drug Res Inst, WELBIO Walloon Excellence Life Sci & BIOtech, B-1200 Brussels, Belgium

[5] INRA, MetaGenoPolis US1367, Jouy En Josas, France

[6] AgroParisTech, MICALIS UMR1319, Jouy En Josas, France

[7] Univ London Imperial Coll Sci Technol & Med, Sect Biomol Med, Div Computat & Syst Med, Dept Surg & Canc,Fac Med, London, England

来源：

GUT | 2016年 / 65卷 / 03期

关键词：

INSULIN-RESISTANCE; GASTRIC BYPASS; BARIATRIC SURGERY; ADIPOCYTE SIZE; GLUCOSE; HOST; SENSITIVITY; METAGENOME; POPULATION; EXPRESSION;

D O I：

10.1136/gutjnl-2014-308778

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective Individuals with obesity and type 2 diabetes differ from lean and healthy individuals in their abundance of certain gut microbial species and microbial gene richness. Abundance of Akkermansia muciniphila, a mucin-degrading bacterium, has been inversely associated with body fat mass and glucose intolerance in mice, but more evidence is needed in humans. The impact of diet and weight loss on this bacterial species is unknown. Our objective was to evaluate the association between faecal A. muciniphila abundance, faecal microbiome gene richness, diet, host characteristics, and their changes after calorie restriction (CR). Design The intervention consisted of a 6-week CR period followed by a 6-week weight stabilisation diet in overweight and obese adults (N=49, including 41 women). Faecal A. muciniphila abundance, faecal microbial gene richness, diet and bioclinical parameters were measured at baseline and after CR and weight stabilisation. Results At baseline A. muciniphila was inversely related to fasting glucose, waist-to-hip ratio and subcutaneous adipocyte diameter. Subjects with higher gene richness and A. muciniphila abundance exhibited the healthiest metabolic status, particularly in fasting plasma glucose, plasma triglycerides and body fat distribution. Individuals with higher baseline A. muciniphila displayed greater improvement in insulin sensitivity markers and other clinical parameters after CR. These participants also experienced a reduction in A. muciniphila abundance, but it remained significantly higher than in individuals with lower baseline abundance. A. muciniphila was associated with microbial species known to be related to health. Conclusions A. muciniphila is associated with a healthier metabolic status and better clinical outcomes after CR in overweight/obese adults. The interaction between gut microbiota ecology and A. muciniphila warrants further investigation.

引用

页码：426 / 436

页数：11

共 65 条

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