Glycemic variability in the development of cardiovascular complications in diabetes

被引：136

作者：

Nusca, Annunziata ^{[1
]}

Tuccinardi, Dario ^{[2
]}

Albano, Marzia ^{[1
]}

Cavallaro, Camilla ^{[1
]}

Ricottini, Elisabetta ^{[1
]}

Manfrini, Silvia ^{[2
]}

Pozzilli, Paolo ^{[2
]}

Di Sciascio, Germano ^{[1
]}

机构：

[1] Campus Biomed Univ Rome, Unit Cardiac Sci, Via Alvaro del Portillo 200, I-00128 Rome, Italy

[2] Campus Biomed Univ Rome, Dept Med, Unit Endocrinol & Diabet, Rome, Italy

来源：

DIABETES-METABOLISM RESEARCH AND REVIEWS | 2018年 / 34卷 / 08期

关键词：

cardiovascular complications; coronary artery disease; diabetes mellitus; glycemic variability; ACUTE GLUCOSE FLUCTUATIONS; EVEROLIMUS-ELUTING STENT; FASTING PLASMA-GLUCOSE; LONG-TERM INSTABILITY; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; BLOOD-GLUCOSE; GLYCOSYLATED HEMOGLOBIN; ENDOTHELIAL FUNCTION; ENHANCES APOPTOSIS;

D O I：

10.1002/dmrr.3047

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes mellitus represents a major risk factor for the development of coronary artery disease and other vascular complications. Glycated haemoglobin, fructosamine, and fasting blood glucose levels are partial parameters to exhaustively describe patient dysglycemic status. Thus, recently the new concept of glycemic variability has emerged, including information about two major aspects: the magnitude of blood glucose excursions (from nadir to peak, thus lower and higher spikes) and the time intervals in which these fluctuations occur. Despite the lack of consensus regarding the most appropriate definition and tools for its assessment, glycemic variability seems to have more deleterious effects than sustained hyperglycemia in the pathogenesis of diabetic cardiovascular complications. This manuscript aimed to review the most recent evidence on glycemic variability and its potential use in everyday clinical practice to identify diabetic patients at higher risk of cardiovascular complications and thus needing stricter monitoring and treatment.

引用

页数：10