Microtubule Minus-End-Targeting Proteins

被引:152
作者
Akhmanova, Anna [1 ]
Hoogenraad, Casper C. [1 ]
机构
[1] Univ Utrecht, Fac Sci, NL-3584 CH Utrecht, Netherlands
基金
欧洲研究理事会;
关键词
POLARIZED EPITHELIAL-CELLS; XENOPUS EGG EXTRACTS; DYNAMIC INSTABILITY; MITOTIC SPINDLE; BINDING-PROTEIN; PLUS-END; NONCENTROSOMAL MICROTUBULES; CAENORHABDITIS-ELEGANS; NEURONAL MICROTUBULES; ADHERENS JUNCTIONS;
D O I
10.1016/j.cub.2014.12.027
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Microtubules are cytoskeletal filaments that are intrinsically polarized, with two structurally and functionally distinct ends, the plus end and the minus end. Over the last decade, numerous studies have shown that microtubule plus-end dynamics play an important role in many vital cellular processes and are controlled by numerous factors, such as microtubule plus-end-tracking proteins (+TIPs). In contrast, the cellular machinery that controls the behavior and organization of microtubule minus ends remains one of the least well-understood facets of the microtubule cytoskeleton. The recent characterization of the CAMSAP/Patronin/Nezha family members as specific 'minus-end-targeting proteins' ('-TIPs') has provided important new insights into the mechanisms governing minus-end dynamics. Here, we review the current state of knowledge on how microtubule minus ends are controlled and how minus-end regulators contribute to non-centrosomal microtubule organization and function during cell division, migration and differentiation.
引用
收藏
页码:R162 / R171
页数:10
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