Regioselective C-H Phosphorothiolation of (Hetero)arenes Enabled by the Synergy of Electrooxidation and Ultrasonic Irradiation

被引：49
作者：
Meng, Ze-Yin [1 ,2 ]
Feng, Cheng-Tao [1 ,2 ]
Zhang, Ling [2 ]
Yang, Qing [2 ]
Chen, De-Xiang [2 ]
Xu, Kun [3 ]
机构：
[1] Anhui Univ Chinese Med, Sch Pharm, Hefei 230012, Peoples R China
[2] Anhui Univ Sci & Technol, Sch Chem Engn, Huainan 232001, Peoples R China
[3] Beijing Univ Technol, Fac Environm & Life, Beijing 100124, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 11期
关键词：
ARYL; ACIDS;
D O I：
10.1021/acs.orglett.1c01161
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An electrochemically regioselective C-H phosphorothiolation of (hetero)arenes with thiocyanate as the S source under ultrasonic irradiation has been developed. The synergistic cooperation of electrooxidation and ultrasonication markedly accelerated the C-H phosphorothiolation reaction. This mechanistically different method is distinguished by its wide substrate scope and transition-metal-free and external-oxidant-free conditions, thus complementing the existing metal-catalyzed or peroxide-mediated protocols for the green synthesis of S-(hetero)aryl phosphorothioates.
引用
收藏
页码：4214 / 4218
页数：5
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