Smooth pursuit eye movement deficits as a biomarker for psychotic features in bipolar disorder-Findings from the PARDIP study

被引:14
作者
Brakemeier, Svenja [1 ]
Sprenger, Andreas [2 ]
Meyhoefer, Inga [1 ,3 ]
McDowell, Jennifer E. [4 ,5 ]
Rubin, Leah H. [6 ]
Hill, S. Kristian [7 ]
Keshavan, Matcheri S. [8 ]
Pearlson, Godfrey D. [9 ,10 ,11 ]
Tamminga, Carol A. [12 ]
Gershon, Elliot S. [13 ]
Keedy, Sarah S. [13 ]
Sweeney, John A. [14 ]
Clementz, Brett A. [4 ,5 ]
Lencer, Rebekka [1 ,3 ]
机构
[1] Univ Munster, Dept Psychiat & Psychotherapy, Albert Schweitzer Campus 1,Geb A9, D-48149 Munster, Germany
[2] Univ Lubeck, Dept Neurol, Lubeck, Germany
[3] Univ Munster, Otto Creutzfeldt Ctr Cognit & Behav Neurosci, Munster, Germany
[4] Univ Georgia, Dept Psychol, Bioimaging Res Ctr, Athens, GA 30602 USA
[5] Univ Georgia, Dept Neurosci, Bioimaging Res Ctr, Athens, GA 30602 USA
[6] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[7] Rosalind Franklin Univ Med & Sci, Dept Psychol, Chicago, IL USA
[8] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Psychiat, Boston, MA 02115 USA
[9] Yale Sch Med, Dept Psychiat, Hartford, CT USA
[10] Yale Sch Med, Dept Neurosci, Hartford, CT USA
[11] Hartford Hosp, Inst Living, Olin Res Ctr, Hartford, CT 06115 USA
[12] Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, Dallas, TX USA
[13] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA
[14] Univ Cincinnati, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA
关键词
eye movements; mood disorders; psychotic disorders; sensorimotor processing; CATCH-UP SACCADES; 1ST-DEGREE RELATIVES; TRACKING DYSFUNCTION; MOTION INFORMATION; SCHIZOPHRENIA; GAIN; ABNORMALITIES; MECHANISMS; PROBANDS; SCALE;
D O I
10.1111/bdi.12865
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives Smooth pursuit eye movement deficits are an established psychosis biomarker across schizophrenia, schizoaffective and psychotic bipolar disorder (BPwP). Whether smooth pursuit deficits are also seen in bipolar disorder without psychosis (BPwoP) is unclear. Here we present data from the Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP) study comparing bipolar patients with and without psychotic features. Methods Probands with BPwP (N = 49) and BPwoP (N = 36), and healthy controls (HC, N = 71) performed eye tracking tasks designed to evaluate specific sensorimotor components relevant for pursuit initiation and pursuit maintenance. Results While BPwoP did not differ from either BPwP or HC on initial eye acceleration, they performed significantly better than BPwP on early (P < .01) and predictive (P = .02) pursuit maintenance measures, both without differing from HC. BPwP were impaired compared to HC on initial eye acceleration, and on early and predictive pursuit maintenance (all P < .01). In contrast to the three pursuit measures, BPwP and BPwoP were both impaired on general neurocognitive assessments in relation to HC (both P < .001), without a significant difference between the two bipolar patient groups. Conclusions Our findings support the model that impairments of sensorimotor and cognitive processing as required for early and later predictive smooth pursuit maintenance are relatively specific to those bipolar patients with a history of psychosis. This suggests that the neural circuitry for developing feed-forward predictive models for accurate pursuit maintenance is associated with the occurrence of psychotic features in bipolar patients. In contrast, generalized neuropsychological impairments did not differentiate the two bipolar patient groups.
引用
收藏
页码:602 / 611
页数:10
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