Novel probiotic evidence of lactobacilli on immunomodulation and regulation of satiety hormones release in intestinal cells

被引：31

作者：

Belguesmia, Yanath ^{[1
]}

Domenger, Dorothee ^{[1
]}

Caron, Juliette ^{[1
]}

Dhulster, Pascal ^{[1
]}

Ravallec, Rozenn ^{[1
]}

Drider, Djamel ^{[1
]}

Cudennec, Benoit ^{[1
]}

机构：

[1] Univ Lille, ICV, EA 7394, USC 1281, F-59000 Lille, France

来源：

JOURNAL OF FUNCTIONAL FOODS | 2016年 / 24卷

关键词：

Lactobacillus; Probiotics; Cytokines; Intestinal hormones; Satiety; Gastrointestinal digestion; LACTIC-ACID BACTERIA; GLUCAGON-LIKE PEPTIDE-1; IN-VITRO EVALUATION; ABDOMINAL ADIPOSITY; PEPTONES STIMULATE; GASSERI SBT2055; STRAINS; ADHESION; GUT; PREBIOTICS;

D O I：

10.1016/j.jff.2016.04.014

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Lactobacilli strains with probiotic traits were tested for their ability to survive to the digestion process modelled during this study. These strains managed to sustain the harsh conditions of the gastric and duodenal phases and showed good adhesion capacities to human Caco-2 cell line. These probiotic microorganisms have survived during these steps, exposed to low pH, high concentration of bile salts and enzymes occurring in the digestion and virtually reached the duodenal compartalent in sufficient amount with limited population loss. These lactobacilli strains appeared to be non-cytotoxic after contact with Caco-2 cells for 24 h. Importantly, some of these strains showed immunomodulatory effect, lowering the pro inflammatory cytokine IL-8 and promoting secretion of the anti-inflammatory IL-10. Besides, Lactobacillus gasseri CMUL34 and Lactobacillus acidophilus CMUL67 strains were able to modulate secretion and expression of two intestinal hormones: the Glucagon-Like Peptide 1 (GLP-1) and the cholecystokinin (CCK) in STC-1 cells. (c) 2016 Elsevier Ltd. All rights reserved.

引用

页码：276 / 286

页数：11

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