Secondary Hemophagocytic Lymphohistiocytosis With Epstein-Barr Virus-Associated Transformed Follicular Lymphoma: A Case Report and Literature Review

被引：0
作者：
Xu, Huan [1 ]
Xu, Xia [2 ]
Cui, Guohui [3 ]
Fang, Jun [3 ]
Chen, Wanxin [3 ]
Xue, Mei [3 ]
Jin, Runming [1 ]
Chen, Hongbo [1 ]
Zhang, Lu [3 ]
Hu, Yu [3 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pediat, Wuhan, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pathol, Wuhan, Peoples R China
[3] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hematol, Wuhan, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
基金：
中国国家自然科学基金;
关键词：
follicular lymphoma; histological transformation; Epstein-Barr virus; hemophagocytic lymphohistiocytosis; bone marrow involvement; INDUCED CYTIDINE DEAMINASE; EBV; ACTIVATION; INFECTION; DIAGNOSIS; AID;
D O I：
10.3389/fonc.2021.681432
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A 58-year-old male was admitted to our hospital due to lasting fever, progressive lymphadenopathy and bicytopenia, with a previously histological diagnosis of follicular lymphoma grade 3a with Epstein-Barr virus-encoded RNA positive one month ago. A second biopsy of axillary lymph node revealed concurrent diffuse large B-cell lymphoma with Epstein-Barr virus-encoded RNA positive. Another diagnosis of hemophagocytic lymphohistiocytosis secondary to Epstein-Barr virus positive diffuse large B-cell lymphoma was further concluded by clinical manifestation, laboratory test and atypical lymphocytes in peripheral-blood smear. After a pulse of steroid pre-phase treatment, the patient's clinical condition deteriorated and died in two weeks. The presence of Epstein-Barr virus infection in patients with follicular lymphoma is associated with more aggressive clinical course and increased risk of high-grade transformation. Hemophagocytic lymphohistiocytosis in response to Epstein-Barr virus infection or lymphoma remains fatal. Early diagnosis and initiation of treatment may improve the outcome.
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页数：6
相关论文
共 26 条
[1]   Hemophagocytic Lymphohistiocytosis [J].
Al-Samkari, Hanny ;
Berliner, Nancy .
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13, 2018, 13 :27-49
[2]  
Ansell SM, 1999, AM J HEMATOL, V60, P99, DOI 10.1002/(SICI)1096-8652(199902)60:2<99::AID-AJH3>3.3.CO
[3]  
2-K
[4]   Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells [J].
Cattoretti, Giorgio ;
Buettner, Maike ;
Shaknovich, Rita ;
Kremmer, Elisabeth ;
Alobeid, Bachir ;
Niedobitek, Gerald .
BLOOD, 2006, 107 (10) :3967-3975
[5]   Treatment of Epstein Barr virus-induced haemophagocytic lymphohistiocytosis with rituximab-containing chemo-immunotherapeutic regimens [J].
Chellapandian, DeepakBabu ;
Das, Rupali ;
Zelley, Kristin ;
Wiener, Susan J. ;
Zhao, Huaqing ;
Teachey, David T. ;
Nichols, Kim E. .
BRITISH JOURNAL OF HAEMATOLOGY, 2013, 162 (03) :376-382
[6]   Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations [J].
Epeldegui, Marta ;
Hung, Yee Ping ;
McQuay, Amy ;
Ambinder, Richard F. ;
Martinez-Maza, Otoniel .
MOLECULAR IMMUNOLOGY, 2007, 44 (05) :934-942
[7]   HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis [J].
Henter, Jan-Inge ;
Horne, AnnaCarin ;
Arico, Maurizio ;
Egeler, R. Maarten ;
Filipovich, Alexandra H. ;
Imashuku, Shinsaku ;
Ladisch, Stephan ;
McClain, Ken ;
Webb, David ;
Winiarski, Jacek ;
Janka, Gritta .
PEDIATRIC BLOOD & CANCER, 2007, 48 (02) :124-131
[8]   Treatment strategies for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) [J].
Imashuku, S ;
Tabata, Y ;
Teramura, T ;
Hibi, S .
LEUKEMIA & LYMPHOMA, 2000, 39 (1-2) :37-49
[9]   Epstein-Barr virus latent membrane protein 1 increases genomic instability through Egr-1-mediated up-regulation of activation-induced cytidine deaminase in B-cell lymphoma [J].
Kim, Joo Hyun ;
Kim, Won Seog ;
Park, Chaehwa .
LEUKEMIA & LYMPHOMA, 2013, 54 (09) :2035-2040
[10]   Synchronous Follicular Lymphoma, Kaposi Sarcoma, and Castleman's Disease in a HIV-Negative Patient With EBV and HHV-8 Coinfection [J].
Koreishi, Aashiyana F. ;
Saenz, Adam J. ;
Arcila, Maria E. ;
Hedvat, Cyrus ;
Fleming, Stephen ;
Teruya-Feldstein, Julie .
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2011, 19 (05) :685-691
123